Evidence map›Paper›PMID 40728216›Full record

ArticleJournal of addiction medicine

The Role of Childhood Trauma in Chronic Pain and Substance Use Among Individuals Receiving Methadone Treatment for Opioid Use Disorder.

Gabriel P A Costa, Jocelyn Ra, Julia Meyerovich, Brian Pittman, Julio C Nunes, Joao P De Aquino

Abstract read
In one paragraph

Article in Journal of addiction medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gabriel P A CostaORCID 0009-0007-8702-5436
Jocelyn Ra
Julia Meyerovich
Brian Pittman
Julio C Nunes

Funding

HEAL Initiative: Integrative Management of chronic Pain and OUD for Whole Recovery (IMPOWR): Research CentersRM1DA055310 · NIDA · YALE UNIVERSITY · PI BARRY, DECLAN T., BECKER, WILLIAM C · 2021 to 2025
$12.9M
Schizophrenia Research FellowshipR25MH071584 · NIMH · YALE UNIVERSITY · PI Christopher John Pittenger · 2005 to 2026
$4.4M
Cannabidiol Pharmacotherapy for Comorbid Opioid Addiction and Chronic PainK23DA052682 · NIDA · YALE UNIVERSITY · PI DE AQUINO, JOAO PAULO · 2021 to 2025
$959k
Pharmacokinetics and Pharmacodynamics of Oral and Vaporized THC in Older AdultsR21DA057240 · NIDA · YALE UNIVERSITY · PI DE AQUINO, JOAO PAULO · 2022 to 2023
$360k
NIDA NIH HHS K23 DA052682NIDA NIH HHS R21 DA057240NIDA NIH HHS RM1 DA055310NIH Research Training R25MH071584NIMH NIH HHS R25 MH071584
6 · The paper itself

Abstract

objectivesThis study explored the correlations between childhood trauma, chronic pain, and substance use among individuals receiving methadone for opioid use disorder (OUD). We hypothesized that, among individuals with OUD, a history of childhood trauma would correlate with more severe pain and substance use compared with those without such history.

methodsWe conducted a cross-sectional study of 82 individuals receiving methadone for OUD. Participants completed the Childhood Trauma Questionnaire (CTQ) to assess childhood trauma exposure, the Brief Pain Inventory (BPI) to characterize chronic pain, and the Timeline Followback (TLFB) method to assess substance use in the past 28 days. Correlation analyses and ANOVA examined the relationships between these variables.

resultsHigher childhood trauma scores correlated with greater pain severity (r = 0.27, P = 0.03), increased alcohol consumption (r = 0.25, P = 0.04), and earlier age of cannabis initiation (r = -0.45, P < 0.001). Among trauma subscales, emotional abuse most closely correlated with greater pain severity (r = 0.33, P = 0.008) and interference (r = 0.28, P = 0.03), and alcohol consumption (r = 0.28, P = 0.02). Individuals who used cannabis reported significantly higher levels of emotional abuse ( P = 0.04), sexual abuse ( P = 0.03), and physical neglect ( P = 0.02) compared with those who did not. Conversely, our analysis did not reveal significant correlations between childhood trauma and heroin, tobacco, cocaine, or stimulant use.

conclusionsChildhood trauma correlated with greater pain severity and interference, higher alcohol use, earlier cannabis initiation, and increased likelihood of cannabis use among individuals receiving methadone for OUD. These findings suggest the importance of integrating trauma-focused assessment and treatment into OUD treatment programs.

Indexed as

Chronic PainMethadoneOpiate Substitution TreatmentOpioid-Related DisordersAdultAlcohol DrinkingAnalgesics, OpioidCross-Sectional StudiesFemaleHumansMaleMiddle AgedAnalgesics, OpioidMethadonealcoholcannabischildhood traumachronic painopioid use disorder

Identifiers

PMID40728216
PMCPMC13166079

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.