ArticleJournal of the American Heart Association2025
Synergistic Effects of Type D ("Distressed") Personality Traits on Coronary Microvascular Function in Male Physicians With Occupational Burnout: A Cross-Sectional Study.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Comparative Analysis of the Association of Biomarkers of Endothelial Dysfunction and Systemic Inflammation in Patients with Coronary Artery Disease with the Presence/Absence of Personality Type D.Journal of clinical medicine · 2026Article
- Burnout, resilience, and cardiometabolic phenotype in an academic medical faculty: an integrated cross-sectional assessment from the United Arab Emirates.Frontiers in endocrinology · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPsychosocial factors like type D personality (TDP) and occupational burnout are associated with increased coronary artery disease risk. This cross-sectional study investigated a potential mechanism linking TDP, characterized by negative affectivity (NA) and social inhibition (SI), to coronary microvascular function in male physicians and examined burnout's potential moderating role through a balanced, stratified design.
methodsSixty male physicians, evenly divided into burnout and nonburnout groups, underwent positron emission tomography to measure endothelium-dependent coronary flow reserve (CFR) during the cold pressor test and endothelium-independent CFR during adenosine-induced hyperemia. TDP effects were primarily analyzed using a dimensional approach based on continuous NA and SI scores and their interaction, adjusting for physical activity and Systematic Coronary Risk Evaluation 2 or age and metabolic syndrome factors.
resultsFourteen participants (23.3%) exhibited TDP (NA and SI scores ≥10), with 92.9% also experiencing burnout. Moderator analysis was limited by the high co-occurrence of burnout and TDP. A significant positive NA×SI interaction was associated with increased endothelium-dependent CFR, independent of burnout, physical activity, and either Systematic Coronary Risk Evaluation 2 (
conclusionsTDP components may synergistically affect coronary microvascular function via heightened sympathetic activity. Exaggerated CFR during sympathetic stimulation may reflect a compensatory or early-stage response, potentially indicative of maladaptive hyperemia and future microvascular impairment.
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