Observational studyJournal of the American Heart Association2025
Fetal Conduction Disease and Arrhythmia in Ebstein's Anomaly and Tricuspid Valve Dysplasia Assessed by Fetal Magnetocardiography.
Observational study in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03047161 (Electrophysiology of Fetal Arrhythmia), which is not on this map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Electrophysiology of Fetal Arrhythmia
Who cites it
3 citing papers in PubMed.
- Ambulatory Fetal Heart Rate and Rhythm Monitoring for Pregnancies at Risk for Fetal Arrhythmias: Perspectives from the Fetal Heart Society.Pediatric cardiology · 2026Review
- OPM-based fetal magnetocardiography: fetal cardiac time intervals in healthy pregnancies compared to postnatal ECGs.Archives of gynecology and obstetrics · 2026Article
- Fe-Based Nanocrystalline Magnetic Shielding Cylinder with Subfemtotesla-Level Magnetic Noise.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundEbstein's anomaly and tricuspid valve dysplasia are associated with perinatal mortality approaching 50% and are among the most difficult fetal conditions to manage. Prediction of perinatal mortality is difficult and remains an active area of research. The usefulness of electrophysiologic indicators has not been investigated.
methodsEighteen fetuses with a diagnosis of Ebstein's anomaly and tricuspid valve dysplasia were referred for fetal magnetocardiography evaluation. We assessed fetal rhythm, waveform intervals, and heart rate variability and reactivity.
resultsTwo subjects were lost to follow-up and 1 remains in utero. Of the other 15, 6 (40%) did not survive: 5 died within the first month of life, and 1 died at 4 months following surgery. Compared with normal fetuses, the Ebstein's anomaly and tricuspid valve dysplasia group exhibited significantly prolonged P-wave duration (
conclusionsEbstein's anomaly and tricuspid valve dysplasia manifests distinct conduction and rhythm abnormalities detectable by fetal magnetocardiography but not by echocardiography. These electrophysiologic markers were associated with perinatal mortality and may serve as useful prognostic indicators. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT03047161.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.