Evidence map›Paper›PMID 40728157›Full record

ReviewJournal of the American Heart Association2025

Combined Percutaneous Left Atrial Appendage Closure and Mitral Transcatheter Edge-to-Edge Repair: Current Evidence and Practical Considerations.

Michele Galasso, Michele Morosato, Greta Cattaneo, Alfonso Ielasi, Diego Maffeo, Cosmo Godino

Abstract readReview
In one paragraph

Review in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Michele GalassoSchool of Medicine and Surgery Milano-Bicocca University Milan Italy.
Michele MorosatoCardiology Unit IRCCS Ospedale San Raffaele Milan Italy.ORCID 0009-0005-7946-9382
Greta CattaneoInterventional Cardiology Unit Fondazione Poliambulanza Brescia Italy.ORCID 0009-0007-3223-8493
Alfonso IelasiU.O. Cardiologia Ospedaliera IRCCS Galeazzi Sant'Ambrogio Hospital Milan Italy.
Diego MaffeoInterventional Cardiology Unit Fondazione Poliambulanza Brescia Italy.ORCID 0000-0002-6320-2959
Cosmo GodinoCardiology Unit IRCCS Ospedale San Raffaele Milan Italy.ORCID 0000-0003-1319-0010

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atrial fibrillation commonly coexists with severe mitral regurgitation, complicating management by necessitating long-term anticoagulation, with its associated bleeding risk. The combined approach of percutaneous left atrial appendage closure and mitral transcatheter edge-to-edge repair has been proposed as a comprehensive solution, mitigating stroke risk while addressing mitral regurgitation. This approach eliminates the need for a second procedure and lifelong oral anticoagulants. Our review provides insights into the benefits and risks of combined procedures, potentially aiding clinicians in optimizing management for these patients. Long-term follow-up will determine whether combining these interventions improves prognosis in high-risk patients with atrial fibrillation.

Indexed as

Atrial AppendageAtrial FibrillationCardiac CatheterizationMitral ValveMitral Valve InsufficiencyStrokeHumansLeft Atrial Appendage ClosureRisk FactorsTreatment Outcomeatrial fibrillationcombined procedureleft atrial appendage closuremitral transcatheter edge‐to‐edge repair

Identifiers

PMID40728157
PMCPMC12450008

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.