Observational studyOtolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery2025
Otitis Media Trial Publication After ClinicalTrials.gov Registration.
Observational study in Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- A literature review and reflection on clinical trials: current challenges, future directions, and potential strategies to overcome practical barriers.AME clinical trials review · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the proportion of completed otitis media (OM) clinical trials registered on ClinicalTrials.gov and identify factors associated with nonpublication. STUDY
designCross-sectional observational study.
settingClinicalTrials.gov registry and peer-reviewed literature databases.
methodsClinicalTrials.gov was queried for completed OM-related trials with primary completion dates before January 1, 2022. Trials were categorized by intervention type, sponsorship, phase, age group, and principal investigator location. Publication status was determined through systematic searches of ClinicalTrials.gov, PubMed, and Google Scholar. Multivariable logistic regression identified factors associated with publication.
resultsOf 256 completed OM trials, only 18.4% (47) were published. Biologic trials-primarily studies evaluating pneumococcal conjugate vaccines (PCVs)-had the highest proportion published (81.3%), followed by drug trials (20.5%), procedure trials (18.8%), device trials (8.9%), and other trials (8.0%). Interventional trials were more frequently published than observational trials (24.2% vs 2.9%). In multivariable analysis, biologic interventions, interventional study design, and child-focused studies were significant predictors of publication. Drug, device, and procedure trials had significantly lower odds of publication compared to biologics. Adult-only studies and observational trials were also less likely to be published.
conclusionFewer than 1 in 5 OM trials were published-a proportion substantially lower than in other otolaryngology subspecialties. While PCV trials had high publication proportions, most other categories lagged. Greater investment across the research pipeline is needed to drive innovation in OM therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.