Evidence map›Paper›PMID 40728096›Full record

ArticleImmunity, inflammation and disease2025

Characteristics of Corticosteroid-Resistant Secondary Immune Thrombocytopenia Associated With Connective Tissue Diseases in China: A Retrospective Comparative Study.

Yangchun Chen, Yingying Shi, Yuechi Sun, Yun Peng, Guixiu Shi, Yuan Liu, Shiju Chen

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, inflammation and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yangchun ChenDepartment of Rheumatology and Clinical Immunology, School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen, China.ORCID 0000-0002-8287-9893
Yingying ShiDepartment of Rheumatology and Clinical Immunology, School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen, China.
Yuechi SunDepartment of Rheumatology and Clinical Immunology, School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen, China.ORCID 0000-0001-6456-0363
Yun PengDepartment of Rheumatology and Clinical Immunology, School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen, China.
Guixiu ShiDepartment of Rheumatology and Clinical Immunology, School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen, China.
Yuan LiuDepartment of Rheumatology and Clinical Immunology, School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen, China.ORCID 0000-0003-2668-0350
Shiju ChenDepartment of Rheumatology and Clinical Immunology, School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen, China.ORCID 0000-0002-8165-0448

Funding

This work was supported by the Fujian Science and Technology Project 2020J05309 to S.J.C. and 2023J06055 to Y.L., the Natural Science Foundation of Xiamen Municipality 3502Z20227341 to Y.C.C. and 3502Z20244ZD1005 to S.J.C.
6 · The paper itself

Abstract

objectiveCorticosteroid-resistant secondary immune thrombocytopenia (ITP) is a challenging condition in clinical practice. This study aimed to explore the clinical and immunological characteristics of corticosteroid-resistant secondary ITP associated with connective tissue diseases (CTD-ITP).

methodsWe conducted a retrospective analysis of 201 CTD-ITP hospitalized patients between 2014 and 2022. Patients were categorized as corticosteroid-resistant or corticosteroid-sensitive, and their demographic, clinical, and immunological data were compared. Logistic regression analysis was employed to identify independent predictors of corticosteroid resistance.

resultsCorticosteroid resistance was observed in 27.4% of patients. Compared with the corticosteroid-sensitive group, the corticosteroid-resistant group exhibited a higher percentage of CD3

conclusionThis study revealed the potential role of higher CD3

Indexed as

Adrenal Cortex HormonesConnective Tissue DiseasesDrug ResistancePurpura, Thrombocytopenic, IdiopathicAdultAgedChinaFemaleHumansMaleMiddle AgedRetrospective StudiesAdrenal Cortex HormonesCD8+ T cell percentageconnective tissue diseasecorticosteroid‐resistantsecondary immune thrombocytopenia

Identifiers

PMID40728096
PMCPMC12305458

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.