Evidence map›Paper›PMID 40727944›Full record

ArticleJournal of pharmaceutical analysis2025

Ginkgolic acid inhibits CD8

Sai Zhang, Zhuyuan Si, Mingkun Liu, Wenjuan Hao, Tong Xia, Zeyang Liu, Gang Du, Bin Jin

Abstract read
In one paragraph

Article in Journal of pharmaceutical analysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sai ZhangDepartment of Organ Transplantation, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China.
Zhuyuan SiDepartment of Organ Transplantation, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China.
Mingkun LiuDepartment of Organ Transplantation, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China.
Wenjuan HaoDepartment of Organ Transplantation, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China.
Tong XiaDepartment of Organ Transplantation, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China.
Zeyang LiuDepartment of Organ Transplantation, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China.
Gang DuDepartment of Organ Transplantation, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China.
Bin JinDepartment of Organ Transplantation, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the context of the development of transplant oncology, it is of great clinical significance to find a drug with both antitumor and immunosuppressive effects for liver transplantation patients with hepatocellular carcinoma (HCC). The antitumor effect of ginkgolic acid (GA) has been confirmed, and some studies suggest that GA may also have an immunosuppressive effect. The immunosuppressive effect of GA was evaluated by histopathology, T-cell subpopulation, and cytokine detection in rat liver transplantation and mouse cardiac transplantation models, and transcriptomic and metabolomic analysis was used to explore the underlying mechanism of the GA immunosuppressive effect. Metabolites, activation, and ferroptosis markers of CD8

Indexed as

CD8+ T cellFerroptosisGinkgolic acidImmunosuppressiveLDHA

Identifiers

PMID40727944
PMCPMC12303057

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.