Evidence map›Paper›PMID 40727942›Full record

ArticleiScience2025

Drug delivery agent that acts as a drug for synergistic activity.

Ke Li, Ullas V Chembazhi, Sarah B Krueger, Zachary Dewald, Junfeng Chen, Yugang Bai, Dongwook Kim, Amie N Lanzendorf, Philip A Kocheril, Jie Chen and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ke LiDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Ullas V ChembazhiDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Sarah B KruegerDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Zachary DewaldDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Junfeng ChenDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Yugang BaiDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Dongwook KimDepartment of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Amie N LanzendorfDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Philip A KocherilDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Jie ChenDepartment of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Auinash KalsotraDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Steven C ZimmermanDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.

Funding

Post-transcriptional mechanisms of gene regulation in cardiac cell growth and developmentR01HL126845 · NHLBI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI KALSOTRA, AUINASH · 2015 to 2023
$3.5M
Small Molecule Approaches to Targeting the DNA and RNA in Myotonic DystrophyR01AR069645 · NIAMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI ZIMMERMAN, STEVEN C. · 2017 to 2021
$2.2M
NHLBI NIH HHS R01 HL126845NIAMS NIH HHS R01 AR069645
6 · The paper itself

Abstract

Drug delivery vehicles increase cell permeability of their cargo, but otherwise are expected to be inert. In developing a potential strategy to treat myotonic dystrophy type 1, we developed a delivery vehicle that was designed to be a direct acting drug. The oligomeric delivery agent selectively targets the expanded DNA and RNA repeat sequences (d(CTG)

Indexed as

BiochemistryBiological sciencesNatural sciencesPathophysiologyPhysiology

Identifiers

PMID40727942
PMCPMC12302617

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.