Evidence map›Paper›PMID 40727939›Full record

ArticleiScience2025

B- and T cell receptor sequencing elucidates characteristics of lymphocyte depletion by ocrelizumab.

Tilman Schneider-Hohendorf, Christian Wünsch, Andreas Schulte-Mecklenbeck, Lisa Revie, Catarina Raposo, Nicolas Strauli, Björn Tackenberg, Jan D Lünemann, Catharina C Gross, Luisa Klotz and 2 more

Abstract read
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tilman Schneider-HohendorfDepartment of Neurology, University Hospital Muenster, Muenster, Germany.
Christian WünschDepartment of Neurology, University Hospital Muenster, Muenster, Germany.
Andreas Schulte-MecklenbeckDepartment of Neurology, University Hospital Muenster, Muenster, Germany.
Lisa RevieDepartment of Neurology, University Hospital Muenster, Muenster, Germany.
Catarina RaposoF. Hoffmann-La Roche Ltd, Basel, Switzerland.
Nicolas StrauliGenentech, San Francisco, CA, USA.
Björn TackenbergF. Hoffmann-La Roche Ltd, Basel, Switzerland.
Jan D LünemannDepartment of Neurology, University Hospital Muenster, Muenster, Germany.
Catharina C GrossDepartment of Neurology, University Hospital Muenster, Muenster, Germany.
Luisa KlotzDepartment of Neurology, University Hospital Muenster, Muenster, Germany.
Heinz WiendlDepartment of Neurology, University Hospital Muenster, Muenster, Germany.
Nicholas SchwabDepartment of Neurology, University Hospital Muenster, Muenster, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ocrelizumab therapy depletes circulating CD20

Indexed as

Immune responseOmicsTherapy

Identifiers

PMID40727939
PMCPMC12302243

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.