ArticleiScience2025
Phosphorylated Y14 condensates as a scaffold for DNA double-strand break repair.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- The Polymers of Life: Exploring Cellular Function Through Polymer Concepts.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Various DNA damage response factors form biomolecular condensates at DNA lesions. Targeting phase separation in DNA repair factor assemblies may provide a potential anticancer strategy. An RNA-binding protein, Y14/RBM8A, facilitates the repair of DNA double-strand breaks (DSBs) via its RNA-mediated interaction with non-homologous end joining (NHEJ) factors. HaloTag-Y14 fusion is distributed to laser-induced DNA damage sites in an RNA-dependent manner. Serine/arginine (SR) protein kinase 1-mediated phosphorylation of Y14 was also crucial for its localization at DNA lesions and function in DSB repair. Magnesium promoted liquid-liquid phase separation of phosphorylated Y14
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