ArticleiScience2025
Respiratory infection with Enterovirus D68 induces severe acute lung inflammation in the pediatric ferret model.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Characterising the Transcriptomic Response to Interferon and Infection in European Domestic Ferret Respiratory Tissues Using Long-Read RNA Sequencing.Immunology · 2026Article
- Respiratory enterovirus D68: virology, clinical surveillance, host-pathogen interactions, and therapeutic prospects.Frontiers in cellular and infection microbiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Enterovirus D68 (EV-D68) is a reemerging virus that causes severe respiratory disease and polio-like paralysis in children. Here, using a 6-8 weeks old pediatric ferret model, we show that respiratory infection with the 2014 isolate of EV-D68 (US/MO/14-18947) was associated with severe acute respiratory pathology that was characterized by increased airway restriction, cellular infiltration, inducible nitric oxide synthase (iNOS) expression, and apoptosis along with a significant increase in the expression of pro-inflammatory cytokines. All infected ferrets seroconverted with detectable levels of EV-D68 specific binding and neutralizing antibodies in the plasma. Infection was accompanied by a significant increase in the expression of interferon alpha (IFNα) and related genes suggesting a role for potent innate immune responses in acute viral control. These findings were confirmed
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.