Evidence map›Paper›PMID 40727913›Full record

ArticleFrontiers in endocrinology2025

Conventional imaging techniques plus

Wei-Yih Chiu, Kuen-Yuan Chen, Chia-Tung Shun, Ming-Hsun Wu, Keh-Sung Tsai, Ching-Hung Chiu, Wei-Shiung Yang, Ruoh-Fang Yen

Abstract readComparative Study
In one paragraph

Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wei-Yih ChiuDivision of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Kuen-Yuan ChenDivision of General Surgery, Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan.
Chia-Tung ShunDepartment of Pathology, National Taiwan University Hospital, Taipei, Taiwan.
Ming-Hsun WuDivision of General Surgery, Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan.
Keh-Sung TsaiDivision of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Ching-Hung ChiuDepartment of Nuclear Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Wei-Shiung Yang *Division of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Ruoh-Fang Yen *Department of Nuclear Medicine, National Taiwan University Hospital, Taipei, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Currently Methods: All participants underwent US, MIBI, and FCH-PET/CT examinations, and eligible patients underwent parathyroid surgery based on surgical indications and patient preferences. McNemar's test compared diagnostic performance between imaging techniques and Spearman's rank correlation correlated FCH-PET/CT parameters with lesion volume, laboratory, and histological features. Results: 63 out of 83 recruited patients underwent parathyroidectomy. Histologically confirmed parathyroid lesions were found in 69 glands among 63 patients. FCH-PET/CT exhibited higher sensitivity than US, MIBI, and US/MIBI combination (87.0% vs. 49.3%, Conclusions: FCH-PET/CT is effective as a first-line or complementary technique, irrespective of prior US, MIBI or US/MIBI combination. US combined with FCH-PET/CT appears to be the most effective localization strategy among the modalities evaluated in this study. Our findings support an ultrasound-first approach for localizing primary hyperparathyroidism, with FCH-PET/CT referral in uncertain cases to enhance success rates.

Indexed as

AdenomaCholineHyperparathyroidism, PrimaryParathyroid NeoplasmsPositron Emission Tomography Computed TomographyAdultAgedFemaleHumansMaleMiddle AgedParathyroidectomyProspective StudiesRadiopharmaceuticalsTechnetium Tc 99m SestamibiUltrasonographyCholinefluorocholineRadiopharmaceuticalsTechnetium Tc 99m Sestamibi18F-Fluorocholine PET/CTneck ultrasoundparathyroid hormoneprimary hyperparathyroidismtechnetium-99m sestamibi scintigraphy

Identifiers

PMID40727913
PMCPMC12301907

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.