ArticleFrontiers in endocrinology2025
Fatigue in acromegaly patients: a scoping review.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Acromegaly complications: an update.The Journal of clinical endocrinology and metabolism · 2026Review
- The acromegaly patient experience: burden of treatment and quality of life.The Journal of clinical endocrinology and metabolism · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: This scoping review systematically examines current evidence on fatigue in acromegaly patients, with a particular focus on incidence, risk factors, hazards, assessment tools and therapeutic interventions, to inform evidence-based interventions aimed at improving rehabilitation outcomes. Methods: A scoping review was conducted following the PRISMA-ScR guidelines. We systematically searched five international databases (PubMed, Embase, CINAHL, Web of Science, and the Cochrane Library) and three Chinese databases (CNKI [China National Knowledge Infrastructure], WanFang, and Sinomed) from their inception through June 21, 2025. The inclusion criteria included original studies investigating fatigue manifestations in patients with acromegaly, including epidemiological studies, psychometric validation reports, and intervention trials. The exclusion criterion was articles focused exclusively on pharmacological or surgical interventions without fatigue assessment. Two independent researchers performed literature screening, data extraction, and quality appraisal via standardized protocols. Results: A total of 20 studies were included (all English-language publications). The prevalence of fatigue in acromegaly patients is high, ranging from 49% to 92%. Objective fatigue assessment tools primarily involve electromyography (EMG) and isokinetic dynamometry of the knee joint. Subjective fatigue was evaluated with patient self-reports. Factors that influence fatigue in these patients include demographic characteristics, sociological factors, sleep disturbances, comorbidities, and disease-specific factors. Interventions included aerobic exercise, rehabilitation therapist-guided home rehabilitation programs, and cognitive behavioral therapy. Conclusion: This scoping review underscores the need for future large-scale longitudinal studies on fatigue in acromegaly. Priority areas include identifying predictive markers, understanding pathophysiological mechanisms, evaluating targeted interventions, and developing standardized assessment tools to improve early recognition and management.
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Registered trials
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