ReviewTherapeutic advances in medical oncology2025
Advances in immuno-based and targeted therapies in extensive-stage small cell lung cancer.
Review in Therapeutic advances in medical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Article
- A challenge for treating patients with extensive-stage small cell lung cancers, particularly for those with liver metastases.Journal of the Chinese Medical Association : JCMA · 2025Article
- Optimizing outcomes for the patients with extensive-stage small-cell lung cancer.Journal of the Chinese Medical Association : JCMA · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immunotherapy now plays a key role in supplementing and even replacing conventional agents in tumor treatment. Immune checkpoint inhibitors (ICIs), represented by atezolizumab and durvalumab, have shown encouraging therapeutic effects in the combination chemotherapy for extensive-stage small cell lung cancer (SCLC) and have become preferred regimens. It has marked a seminal shift in the treatment landscape with achieving for the first time that overall survival exceed 1 year. However, the extent to which SCLC patients can benefit from ICIs is limited, and ICIs' combination treatment strategies still need to be continuously explored. Beyond the ICIs in combination with radiotherapy, the anti-angiogenic target has been a combination option to improve effectiveness. And the novel formula of immune drugs, such as antibody-drug conjugates, bispecific T cell engager therapy, and chimeric antigen receptor T-cell immunotherapy, also promotes the potential option for SCLC patients. Based on the molecular development and biomarkers analysis of the sensitivity to immune checkpoint of the SCLC subtypes, the exploration of new targets and the development of drugs with novel mechanisms may provide fresh hope for immunotherapy in SCLC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.