SynthesisFrontiers in psychiatry2025
Effect of acupuncture on menopausal depressive disorder and serum hormone levels: a systematic review and meta-analysis.
Synthesis in Frontiers in psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Cost-utility analysis of traditional Korean medicine without acupuncture claims versus integrative care for menopausal disorders: A nationwide retrospective cohort study.Integrative medicine research · 2026Article
- Association between changes in estradiol, serotonin, and BDNF and antidepressant response in perimenopausal depression: a retrospective cohort study comparing integrated TCM-acupuncture with SSRIs.Frontiers in psychiatry · 2026Article
- Efficacy of Acupuncture in Patients with Fibromyalgia Syndrome: A Meta-Analysis.Journal of pain research · 2026Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Menopause, marked by ovarian decline and hormonal shifts, increases vulnerability to depressive disorders, with menopausal depressive disorder (MDD) affecting 33-36% of women via psychosocial-biological interactions. Acupuncture shows promise in improving MDD through neuroendocrine regulation but lacks robust evidence, with unclear links to reproductive hormone modulation; this study evaluates its efficacy and safety. Methods: A comprehensive database search was conducted using PubMed, Embase, the Cochrane Library, Web of Science, EBSCO, Scopus, Cnki, Wan Fang and VIP Database to identify randomized controlled trials (RCTs) investigating the impact of acupuncture on menopausal depressive disorder. RCTs published until April 21, 2025, that met our predetermined inclusion and exclusion criteria were included. Data extraction, literature review, and assessment of the methodological quality of the trials were performed. The meta-analysis was conducted using Review Manager (RevMan) 5.3 software. Results: Our findings demonstrate that acupuncture significantly outperforms control interventions in improving clinical effectiveness rates (OR=2.70, 95%CI[1.63,4.48], P=0.0001) and reducing depressive symptoms, as evidenced by HAMD-17 (SMD=-0.28, P<0.0001) and HAMD-24 scores (post-sensitivity SMD=-0.39, P=0.03). Notably, acupuncture also enhanced quality of life (MENQOL: SMD=-0.25, P=0.003), though its effects on sex hormones (FSH, LH, E2) remained nonsignificant (P>0.05). Safety profiles were comparable between groups (OR=0.16, P=0.05), yet sensitivity analysis revealed reduced adverse events in the acupuncture group after excluding outlier studies (OR=0.49, P=0.03). In conclusion, the intervention of acupuncture is beneficial for MDD. Conclusion: This systematic review demonstrates that acupuncture serves as an effective and safe non-pharmacological intervention for alleviating menopausal depressive symptoms and improving quality of life. While acupuncture did not significantly modulate sex hormone levels, its therapeutic benefits are likely mediated through non-hormonal mechanisms, such as neurotransmitter regulation and neuroendocrine network modulation. Systematic review registration: https://www.crd.york.ac.uk/prospero/, identifier CRD420251037010.
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