ArticleFrontiers in cellular and infection microbiology2025
Epidemiological, clinical, and molecular analysis of human adenovirus infections in hospitalized children with acute respiratory infections in Tianjin, China.
Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Risk factors for hospitalization in pediatric patients with human adenovirus infection and changes in epidemiological and clinical characteristics before and after the COVID-19 pandemic in China: a multicenter retrospective study.Frontiers in cellular and infection microbiology · 2026Article
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6 authors.
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Abstract
Background: Human Adenovirus (HAdV) is a significant pathogen for acute respiratory infections(ARIs) in children. However, its epidemiological patterns, serotype distribution changes, and molecular mechanisms associated with severe pneumonia during and after the COVID-19 pandemic require further elucidation through large-scale and molecular typing studies. Methods: This study used a retrospective cohort design to analyze 28060 respiratory specimens from Tianjin Children's Hospital from March 2022 to March 2024. HAdV detection and typing were performed through targeted high-throughput sequencing and PCR-based amplification of Penton, Hexon, and Fiber genes for phylogenetic analysis. Additionally, clinical data were compared to assess differences in clinical presentations among pediatric patients infected with different HAdV types. Results: The overall HAdV detection rate was 8.9% (2,484/28,060), with significant male predominance (9.2% Conclusion: HAdV-3, HAdV-7, HAdV-2, and HAdV-1 were the predominant HAdV types in children hospitalized with ARIs in Tianjin. Moreover, not only the epidemiological characteristics of different HAdV types vary, but there are also certain differences in the clinical symptoms and outcomes of children infected with different types of HAdV. Therefore, it is essential to differentiate HAdV types for epidemiological surveillance and clinical management purposes.
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