ArticleFrontiers in nutrition2025
Association of prognostic nutritional index with all-cause mortality and cardiovascular mortality: a nationwide population-based cohort study.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Prognostic Value of Inflammatory and Nutritional Indices in Patients Undergoing Permanent Pacemaker Implantation for Degenerative Complete Atrioventricular Block.Medicina (Kaunas, Lithuania) · 2026Article
- Combined Assessment of Immunonutritional Indices and the Triglyceride-Glucose Index in Coronary Slow Flow Phenomenon in a Non-Elderly Population.Journal of clinical medicine · 2026Article
- Integrated routine laboratory indices for risk stratification in HBV-related cirrhosis: a real-world study.BMC gastroenterology · 2026Article
- The prognostic nutritional index improves risk stratification for acute pulmonary embolism.iScience · 2026Article
- Association of Prognostic Nutritional Index With Mortality in High-Risk OSA Individuals and with Disease Severity in Clinical OSA Patients.Nature and science of sleep · 2026Article
- The relationship between prognostic nutritional index and its components (albumin and lymphocyte count) and all-cause mortality in lung cancer patients: a hospital-based study with database external validation.Frontiers in nutrition · 2025Article
- The impact of decreased prognostic nutritional index on the prognosis of patients with pneumonia treated with glucocorticoids: a multicenter retrospective cohort study.Frontiers in nutrition · 2025Article
- Prognostic nutritional index and mortality in pneumonia: a retrospective cohort study in China.Frontiers in nutrition · 2025Article
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Authors and funding
6 authors.
Funding
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Abstract
Background: The prognostic nutritional index (PNI) has shown prognostic value in various diseases, but its association with mortality in the general population remains unclear. Methods: We analyzed data from 30,741 adults in the National Health and Nutrition Examination Survey (NHANES) 2007-2018. Cox proportional hazard models examined the association between PNI and mortality outcomes. Restricted cubic spline analyses were performed to assess non-linear relationships. Subgroup analyses were conducted to evaluate effect modifications. Results: During follow-up, higher PNI values were associated with lower all-cause mortality (HR: 0.95, 95% CI: 0.94-0.96) and cardiovascular mortality (HR: 0.94, 95% CI: 0.93-0.96). Non-linear relationships were identified with threshold effects at PNI = 50.24 for all-cause mortality and PNI = 51.50 for cardiovascular mortality. The protective associations were particularly strong among participants with liver disease ( Conclusion: Prognostic nutritional index demonstrates significant predictive value for mortality outcomes in the general U.S. adult population, with identified threshold effects. These findings suggest PNI's potential utility as a valuable risk stratification tool in clinical practice.
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