ReviewBiophysical reviews2025
Insights on the binding mechanisms and structural dynamics of protamine-DNA interaction.
Review in Biophysical reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Shield strike shatter in DNA topology and nuclease interactions.Nature communications · 2026Article
- In silico evaluation of FDA-approved antivirals and corticosteroids against SARS-CoV-2.Scientific reports · 2026Article
- DNA as Drug Carrier: A Hydrophobic β-Cyclodextrin Channel in a Supramolecular Structure.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been more than a century since the protamines were found. Protamine continues to exist as a nucleo-protamine complex, similar to how the histone does. In sperm cells of vertebrates, protamine binds to DNA to produce compact chromatin. A more densely packed chromatin is produced when protamines replace histones. It is known that protamine is found in the DNA; however, its precise position inside DNA is not clearly known. Protamine may be bound to DNA in the major groove, according to some studies, while others contend that it is located in the minor groove. Also unknown is the precise physics underlying how protamines force histones out of sperm cells. In this work, an integrated view of the nucleo-protein complex formation regarding protamine's binding location in DNA and the phenomena associated with protamine's binding to DNA which is initiated with the eviction of the histones from the coiled chromatin is presented.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.