Evidence map›Paper›PMID 40727662›Full record

ReviewBiophysical reviews2025

Recent advances and perspectives of MicroNeedles for biomedical applications.

Renata Faria Maia, Pedro Machado, Raquel O Rodrigues, Vera Faustino, Helmut Schütte, Stefan Gassmann, Rui A Lima, Graça Minas

Abstract readReview
In one paragraph

Review in Biophysical reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Renata Faria MaiaDepartment of Biomaterials & Biomedical Technology, University Medical Center Groningen, University of Groningen, AB Groningen, The Netherlands.
Pedro MachadoMechanical Engineering Department, MEtRICs, University of Minho, Campus de Azurém, 4800 - 058 Guimarães, Portugal.
Raquel O RodriguesCenter for MicroElectromechanical Systems (CMEMS-UMinho), University of Minho, Campus de Azurém, 4800 - 058 Guimarães, Portugal.
Vera FaustinoCenter for MicroElectromechanical Systems (CMEMS-UMinho), University of Minho, Campus de Azurém, 4800 - 058 Guimarães, Portugal.
Helmut SchütteDep. of Engineering, Jade University of Applied Science, 26389 Wilhelmshaven, Germany.
Stefan GassmannDep. of Engineering, Jade University of Applied Science, 26389 Wilhelmshaven, Germany.
Rui A LimaMechanical Engineering Department, MEtRICs, University of Minho, Campus de Azurém, 4800 - 058 Guimarães, Portugal.
Graça MinasCenter for MicroElectromechanical Systems (CMEMS-UMinho), University of Minho, Campus de Azurém, 4800 - 058 Guimarães, Portugal.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microneedles (MN) technology has emerged as a transformative tool within the biomedical field, offering innovative solutions to challenges in drug delivery, diagnostics, and therapeutic applications. This review article provides an in-depth exploration of the diverse perspectives and applications of MNs, shedding light on their pivotal role in shaping the future of biomedical research and clinical practice. It begins by elucidating the fundamental principles of MNs: design, fabrication techniques, and materials, highlighting their capacity for minimally invasive access to the skin and underlying tissues. These attributes have driven advancements in transdermal drug delivery, facilitating precise and controlled administration of therapeutics, vaccines, and biologics, thus improving patient compliance and treatment outcomes. Furthermore, this review investigates the growing range of applications for MNs, including biomarker extraction, interstitial fluid (ISF) analysis, and continuous glucose monitoring. MNs enable real-time and minimally invasive monitoring of biochemical markers and have the potential to revolutionize disease diagnostics, personalized medicine, and wellness monitoring. Their compatibility with microfluidic systems further enhances their potential for point-of-care testing. This review serves as a comprehensive guide, highlighting the breadth of opportunities and challenges in leveraging MNs to improve healthcare outcomes and emphasizing the need for continued research and development in this dynamic field.

Indexed as

Drug deliveryFluid ExtractionMicrofabricationMicrofluidic DevicesMicroNeedles

Identifiers

PMID40727662
PMCPMC12290160

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.