ArticleFrontiers in bioengineering and biotechnology2025
Integration of co-culture conditions and 3D gelatin methacryloyl hydrogels to improve human-induced pluripotent stem cells-derived cardiomyocytes maturation.
Article in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Engineering the geriatric heart to model HFpEF.Heart failure reviews · 2026Review
- Review
- Design and Characterization of GelMA Nanogels (nanoGelMA) via Desolvation and Photopolymerization for Drug Delivery Applications.Pharmaceutics · 2026Article
- iPSC-Derived Endothelial Cells as Experimental Models for Predictive and Personalized Strategies in Cardiovascular and Cerebrovascular Disease.International journal of molecular sciences · 2026Review
- Biomimetic electrospun scaffolds for engineered heart tissue: from design parameters to drug testing platforms.Frontiers in bioengineering and biotechnology · 2026Review
- Hydrogel-Based Monitoring in Perioperative Anesthesia: A Conceptual Review and Translational Perspective.International journal of nanomedicine · 2026Review
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Authors and funding
19 authors.
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Abstract
Introduction: Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) represent an excellent alternative to animals for Methods: Chemical characterization of custom-synthesized GelMA was performed through Attenuated Total Reflectance Fourier Transformed Infrared (ATR-FTIR) and proton Nuclear Magnetic Resonance ( Results: GelMA was successfully synthesized with two different DoMs (i.e., 30%-40% and 96%-97%) and used to prepare hydrogels at 5%, 7.5% and 10% w/v concentrations. Both GelMA DoM and hydrogel concentration appeared as tuning parameters of gel behavior in aqueous environment at 37°C and mechanical properties, with Young's Modulus of photo-cured gels ranging between Conclusion: Our results demonstrated that the 3D bioengineered model proposed here represents a good replica of the native cardiac tissue environment, improving the hiPSC-CMs maturation profile, thus opening the opportunity for its application in disease modeling and toxicological screening studies.
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