ArticleFrontiers in cardiovascular medicine2025
Association between the triglyceride glucose-waist circumference index and cardiovascular disease across different glycemic statuses among middle-aged and older Chinese adults.
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Associations of triglyceride-glucose-related composite obesity indices with cardiovascular diseases and mortality: a systematic review and meta-analysis.Cardiovascular diabetology · 2026Pooled it
- Association between the cumulative average triglyceride-glucose-waist circumference index and new-onset hypertension among Chinese middle-aged and older adults-a national prospective study.Cardiovascular diabetology. Endocrinology reports · 2026Article
- Controlled Delivery of Gasotransmitters for Cardiovascular Therapy: Molecular Mechanisms, Engineered Platforms, and Translational Perspectives.International journal of nanomedicine · 2026Review
- A novel glycolipid composite index predicting cardiovascular disease in Chinese adults with abnormal glucose metabolism: a nationwide cohort study.Frontiers in cardiovascular medicine · 2026Article
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Authors and funding
6 authors.
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Abstract
Introduction: This study aims to systematically investigate the association between the triglyceride-glucose index multiplied by waist circumference (TyG-WC) and the risk of cardiovascular disease (CVD) and further explore how this relationship varies across different glycemic statuses, including normal glucose regulation (NGR), prediabetes (Pre-DM), and diabetes mellitus (DM). Methods: Data were obtained from the China Health and Retirement Longitudinal Study (CHARLS), including a total of 7,812 middle-aged and older adults. Kaplan-Meier survival analysis, multivariable Cox proportional hazards models, and restricted cubic spline (RCS) regression were employed to assess the association between baseline TyG-WC and incident CVD risk. Subgroup analyses were conducted based on glucose metabolism status to evaluate potential heterogeneity in the associations. Result: During an average follow-up period of 8.25 years, a total of 1,638 incident CVD events were recorded, corresponding to a cumulative incidence of 20.97%. Kaplan-Meier curves showed that individuals in higher TyG-WC strata had significantly greater cumulative CVD incidence compared to those in lower strata across all glucose metabolism categories (log-rank test, Conclusion: TyG-WC is a practical and effective metabolic indicator for evaluating CVD risk among middle-aged and older Chinese adults. Its clinical application may facilitate early identification and precise stratification of high-risk individuals, thereby providing strong support for CVD prevention and targeted intervention strategies.
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