Evidence map›Paper›PMID 40727487›Full record

ArticleSynthetic and systems biotechnology2025

Extracellular vesicles enhance the efficacy of ceftiofur against intracellular bacterial infections.

Pingping Yuan, Shijie Zhou, Qianqian Li, Lin Li, Shaoqi Qu

Abstract read
In one paragraph

Article in Synthetic and systems biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Pingping YuanCollege of Veterinary Medicine, Anhui Agricultural University, Hefei, 230036, China.
Shijie ZhouCollege of Veterinary Medicine, Anhui Agricultural University, Hefei, 230036, China.
Qianqian LiCollege of Veterinary Medicine, Anhui Agricultural University, Hefei, 230036, China.
Lin LiCollege of Veterinary Medicine, Anhui Agricultural University, Hefei, 230036, China.
Shaoqi QuCollege of Veterinary Medicine, Anhui Agricultural University, Hefei, 230036, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacterial infections pose a major threat to human health and economic stability. In particular, intracellular bacterial infections present significant clinical challenges due to antibiotic resistance and poor drug penetration. Therefore, there is an urgent need to develop novel therapeutic strategies to address the problem of intracellular bacterial infections. Extracellular bacterial vesicles become ideal delivery systems due to their natural targeting properties. Here, we developed a bacteria-derived extracellular vesicles (EVs)-based drug delivery platform to enhance the therapeutic efficacy of antibiotics against intracellular infections. EVs were successfully isolated and increased production from

Indexed as

AntibioticBacteriaExtracellular vesiclesIntracellular bacterial infections

Identifiers

PMID40727487
PMCPMC12301761

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.