ArticleJournal of inflammation research2025
The Improvement of Intestinal Mucosal Epithelial Barrier Integrity by 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-
Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- The anti-diarrheal role of iron in piglets: Regulation of colonic goblet cell function.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Amelioration of colitis through restored gut ecology using Christensenella intestinihominis AF73-05CM02 as a probiotic in mice.Communications biology · 2026Article
- The Dietary Polyphenol Resveratrol in Intestinal Ischemia-Reperfusion Injury: From Multifaceted Protective Mechanisms to Clinical Translation Challenges.Food science & nutrition · 2026Review
Corrections and comments
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Authors and funding
11 authors.
Funding
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Abstract
Background and Purpose: The intestinal mucosal barrier is a complex structure that separates the internal and lumen environments. An impaired intestinal barrier may lead to excessive mucosal immune system activation and further to intestinal diseases, including inflammatory bowel disease (IBD). Therefore, improving the integrity of the intestinal barrier may be a therapeutic approach to prevent or treat IBD. In this study, we aimed to elucidate the effects of the new 1,3,4-oxadiazole derivatives of pyrrolo[3,4- Methods: In this study, we used biobank colon and feces samples collected during our previous original experiment, in which we induced colitis in rats by trinitrobenzenesulfonic acid (TNBS) administration. We assessed the expression of tight junction (TJ) proteins, ie, claudin 1 (CLDN1), occludin (OCLN), zonula occludens 1 (ZO1), and mucus layers proteins, ie, mucin 2 (Muc2) and trefoil factor 3 (TFF3), and the goblet cells and mucus content in colon tissues. We also assessed matrix metalloproteinase 9 (MMP9) and MAP kinases (MAPKs) levels in colon tissues and the level of α1-antitrypsin (α1-AT) in feces samples. Results: We found that compounds Conclusion: New pyrrolo[3,4-
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