Evidence map›Paper›PMID 40727436›Full record

ArticleResuscitation plus2025

Predictors of response to peri-arrest bolus epinephrine in children.

Jill L Sorcher, Harshannie Kundun, Shivani Mehta, Anne V Grossestreuer, Michael W Donnino, Monica E Kleinman, Catherine E Ross

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Resuscitation plus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jill L SorcherDivision of Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine., Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Harshannie KundunDivision of Medical Critical Care, Department of Pediatrics Boston Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.
Shivani MehtaNew York Institute of Technology of Osteopathic Medicine, Old Westbury, NY 11568, USA.
Anne V GrossestreuerCenter for Resuscitation Science, Department of Emergency Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 359 Brookline Avenue, Boston, MA 02115, USA.
Michael W DonninoCenter for Resuscitation Science, Department of Emergency Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 359 Brookline Avenue, Boston, MA 02115, USA.
Monica E KleinmanDivision of Critical Care Medicine, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115 USA.
Catherine E RossDivision of Medical Critical Care, Department of Pediatrics Boston Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.

Funding

Epinephrine in the Pediatric Intensive Care Unit: A Dose-Effect TrialK23HL148312 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI ROSS, CATHERINE · 2020 to 2024
$1.0M
NHLBI NIH HHS K23 HL148312
6 · The paper itself

Abstract

Aim: To explore clinical characteristics associated with hemodynamic response to initial dosing of peri-arrest bolus epinephrine (PBE) for acute hypotension in the PICU. Methods: Single center retrospective cohort study of patients < 19 years old who received PBE for acute hypotension in the pediatric intensive care units at our institution from April 2017 to September 2023. Change in systolic blood pressure (SBP) was measured within 5 min before and after PBE. Patients were categorized as non-responders if the change in SBP was ≤ 10 mmHg. The primary analysis used a multivariate logistic regression model to determine factors associated with responder status via manual backward stepwise regression. Post-hoc analyses using Pearson correlation assessed the relationship of age, PBE dose, and SBP and DBP response as continuous variables. Results: Of the 180 patients analyzed, 121 (67 %) were classified as responders and 59 (33%) as non-responders. In the multivariate analysis, non-responder status was independently associated with presence of invasive mechanical ventilation (aOR 5.00; 95 % CI: 1.33, 20; Conclusion: Presence of invasive mechanical ventilation and cardiogenic shock were associated with poor response to PBE. As a continuous variable, SBP response to PBE improved with increasing age despite lower weight-based PBE dosing.

Indexed as

Acute hypotensionBlood pressureBolus-dose pressorsEpinephrinePediatric

Identifiers

PMID40727436
PMCPMC12303060

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.