Evidence map›Paper›PMID 40727430›Full record

ArticleDepression and anxiety2025

Associations Between Oral Microbiota Pathogens and Elevated Depressive and Anxiety Symptoms in Men.

Fannie Kerff, Julie A Pasco, Lana J Williams, Felice N Jacka, Amy Loughman, Samantha L Dawson

Abstract read
In one paragraph

Article in Depression and anxiety, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Inflammatory biomarkers and oral microbiome alterations in depression and anxiety disorders: a systematic review.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2026
    Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Fannie KerffInstitute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine and Barwon Health, Deakin University, Geelong, VIC, Australia.ORCID 0009-0000-0634-7468
Julie A PascoInstitute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine and Barwon Health, Deakin University, Geelong, VIC, Australia.ORCID 0000-0002-8968-4714
Lana J WilliamsInstitute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine and Barwon Health, Deakin University, Geelong, VIC, Australia.ORCID 0000-0002-1377-1272
Felice N JackaInstitute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine and Barwon Health, Deakin University, Geelong, VIC, Australia.ORCID 0000-0002-9825-0328
Amy LoughmanInstitute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine and Barwon Health, Deakin University, Geelong, VIC, Australia.ORCID 0000-0002-0257-1443
Samantha L DawsonInstitute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine and Barwon Health, Deakin University, Geelong, VIC, Australia.ORCID 0000-0002-4701-1220

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Systemic inflammation is associated with depression. Certain oral bacterial species contribute to inflammation; however their potential association with mental disorders remains unclear. This study investigated the associations between oral microbiota pathogens and depressive and anxiety symptoms. Data came from 436 men from the Geelong Osteoporosis Study. Oral microbiota was characterized using 16S rRNA sequencing, and an oral pathogen composite was created comprising

Indexed as

AnxietyDepressionMicrobiotaMouthAgedFusobacterium nucleatumHumansMaleMiddle Agedanxietymajor depressive disordermental disordersoral microbiota

Identifiers

PMID40727430
PMCPMC12303655

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.