Evidence map›Paper›PMID 40727412›Full record

ArticleRoyal Society open science2025

Enzyme inhibitory activity of marine alkaloid aaptamines for neurodegenerative diseases: an

Thi Le Anh Nguyen, Hoang Linh Nguyen, Thi My Pham, Dinh Hieu Truong, Thi Chinh Ngo, Mai Suan Li, Duy Quang Dao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Royal Society open science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Thi Le Anh NguyenInstitute of Research and Development, Duy Tan University, Danang, Vietnam.ORCID https://orcid.org/0000-0002-3660-8400
Hoang Linh NguyenSchool of Engineering and Technology, Duy Tan University, Danang, Vietnam.
Thi My PhamFaculty of Pharmacy, School of Medicine and Pharmacy, Duy Tan University, Danang, Vietnam.
Dinh Hieu TruongInstitute of Research and Development, Duy Tan University, Danang, Vietnam.ORCID https://orcid.org/0000-0002-8775-2912
Thi Chinh NgoInstitute of Research and Development, Duy Tan University, Danang, Vietnam.ORCID https://orcid.org/0000-0002-8206-5996
Mai Suan LiInstitute of Physics, Polish Academy of Sciences, Warsaw, Poland.
Duy Quang DaoInstitute of Research and Development, Duy Tan University, Danang, Vietnam.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The enzyme inhibitory activities of a dataset of 28 aaptamines are performed to identify potential multifunctional drugs for neurodegenerative diseases (NDs). First, the drug-like properties and pharmacokinetic (ADMET) study excluded seven molecules, mostly for the non-permeability of the blood-brain barrier. The binding activities of the remaining 21 candidates towards acetylcholinesterase (AChE), monoamine oxidase B (MAOB) and catechol-O-methyltransferase (COMT) enzymes are initially screened by molecular docking. The top binding complexes (

Indexed as

aaptaminesADMETdockingenzyme inhibitionmolecular dynamicsneurodegenerative diseases

Identifiers

PMID40727412
PMCPMC12303110

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.