ArticleQuantitative imaging in medicine and surgery2025
Exploring the incidence rate and imaging differential diagnosis of anterior mediastinal lesions: an 11-year retrospective study based on 2,626 cases.
Article in Quantitative imaging in medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: There are many complex types of anterior mediastinal lesions, and preoperative differential diagnosis is difficult in clinical practice. This study aimed to explore the incidence of different anterior mediastinal lesions and their differential diagnosis based on clinical and imaging features. Methods: We examined the local incidence of anterior mediastinal lesions and their different types in 2,626 patients with anterior mediastinal lesions. Among them, we explored the diagnostic utility of clinical, radiological, and pathological characteristics of 1,809 patients with complete imaging data. Results: The incidence rate of anterior mediastinal lesions was about 0.4%. Thymic epithelial tumors (TETs) showed the highest incidence rate (56.1%), with most patients aged 50-60 years. Lymphoma was the second most common lesion (16.3%). Age, average diameter, boundaries, calcification, average computed tomography (CT) value, surrounding tissues invasion (vascular, pleural, and lung), pericardial effusion, mediastinal enlargement of lymph nodes, and distant metastasis were identified as statistically significant risk factors for distinguishing TETs, with the areas under the curve (AUCs) of the training and validation sets of 0.94 and 0.93, respectively. Average diameter, edges, boundaries, average CT value, surrounding tissue invasion, and mediastinal lymph node enlargement were risk stratification factors for TETs [AUC: 0.865, 95% confidence interval (CI): 0.842-0.888; sensitivity, 72.0%; specificity, 85.6%]. Other malignant tumors included lymphoma, germ cell tumors, hematolymphoid tumors, and mesenchymal tumors. Benign lesions included simple cysts, mature teratomas, mesenchymal tumors, thymic tissue/hyperplasia, giant lymph node hyperplasia, inflammation, and retrosternal goiters. Conclusions: We observed a low incidence rate of anterior mediastinal lesions. Age was associated with various types of anterior mediastinal lesions, with TETs showing the highest incidence. A systematic diagnostic approach for anterior mediastinal lesions can be developed based on the clinical and imaging features.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.