ArticleQuantitative imaging in medicine and surgery2025
Assessing differences in growth and shape between symptomatic and asymptomatic abdominal aortic aneurysms.
Article in Quantitative imaging in medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Three-Dimensional Assessment of Renal Artery Aneurysm Growth Using Vascular Deformation Mapping.Annals of vascular surgery · 2026Article
- A multimodal deep learning model for predicting impending rupture in symptomatic abdominal aortic aneurysms using CTA and clinical data.Frontiers in cardiovascular medicine · 2026Article
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Authors and funding
5 authors.
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Abstract
Background: While the risk of abdominal aortic aneurysm (AAA) rupture typically rises with increasing maximum aortic diameter (Dmax), this metric alone does not reflect the full morphological complexity of AAAs and is inadequate for accurately predicting rupture risk. In this study, we aimed to explore differences in growth and shape between asymptomatic AAA (aAAA) and symptomatic AAA (sAAA). Methods: Patients with infra-renal AAA and ≥2 CTA from 2010-2023 were identified. PRAEVAorta (Nurea, Bordeaux, France) was used to obtain segmentations of the aorta and its branches. Each segmentation was manually reviewed for accuracy using 3D Slicer. Patient demographics, Dmax, AAA flow lumen (AFL), and intraluminal thrombus (ILT) volume were obtained and compared between aAAA and sAAA. A subgroup of aAAA were matched with sAAA on sex and baseline Dmax (12 matched pairs) for comparison of shape, curvature, and 3D-growth. Statistical shape modeling (SSM) derived mean shapes for aAAA and sAAA were compared. Shape [quantified using distance to centerline (DC) in cm], curvature, and 3D-growth (defined as the difference in shape over time) were compared over eight aortic segments. Results: Fifty-five patients with AAA (12 sAAA) were included (47.3% female). Patients with sAAA were younger than those with aAAA [66.0 (60.9, 70.1) Conclusions: sAAA had larger increase in AAA volume and AFL volume over time when compared to aAAA (despite no difference in diameter, volume, or change in diameter). Despite no quantifiable differences in shape or curvature between aAAA and sAAA, sAAA had larger 3D-growth in the left lateral aneurysm neck compared to aAAA. Volumetric changes, shape, and 3D-growth may be better predictors of AAA rupture risk. However, larger scale studies are warranted to confirm these preliminary findings and explore the mechanisms underlying these differences.
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