ArticleQuantitative imaging in medicine and surgery2025
Continuous-time random walk and fractional order calculus models histogram analysis of glioma biomarkers, including
Article in Quantitative imaging in medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Circulating tumor cells as a recurrence risk marker in glioma: a retrospective study.Translational cancer research · 2025Article
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11 authors.
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Abstract
Background: The focus of neuro-oncology research has changed from histopathologic grading to molecular characteristics, and medical imaging routinely follows this change. This study aimed to demonstrate the feasibility of using continuous-time random walk (CTRW) and fractional order calculus (FROC) models, together with histogram analysis, in identifying the states of molecular biomarkers of diffuse gliomas in adults. Methods: A total of 111 diffuse glioma patients undergoing multi-b-value diffusion-weighted imaging (DWI) were included. The histogram parameters of CTRW, FROC, and mono-exponential models were compared between diffuse gliomas with different molecular states [isocitrate dehydrogenase 1 ( Results: Statistically significant differences (P<0.05) were found between Conclusions: The CTRW and FROC models demonstrate good diagnostic performance in predicting different molecular subtypes in diffuse gliomas, and provide new imaging biomarkers for probing tumor structural heterogeneity at a subvoxel level.
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