ArticleQuantitative imaging in medicine and surgery2025
The impaired white-matter structural network mediates the relationship between the glymphatic system and emotional abnormalities in patients with chronic kidney disease.
Article in Quantitative imaging in medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Chronic kidney disease and cognitive decline: choroid plexus remodeling, glymphatic dysfunction, and alzheimer biomarker interpretation.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Patients with chronic kidney disease (CKD) tend to have white-matter network and glymphatic system dysfunction, and may experience cognitive decline and psychiatric abnormalities. This study explored the relationships between graph theory-based white-matter networks and diffusion tensor image analysis along the perivascular space (DTI-ALPS) and the choroid plexus volume (CPV). Methods: Sixty-one CKD patients, including 22 non-dialysis dependent (NDD) and 39 dialysis-dependent (DD) patients, and 43 age-, gender-, and education-matched healthy control (HC) participants were recruited for the study. All participants underwent blood biochemical tests, neuropsychological assessments, and magnetic resonance imaging scans. Preprocessed images were used to construct fractional anisotropy networks, and calculate the DTI-ALPS index and CPV. Intergroup comparisons were performed for all measurements, and correlations were analyzed. Results: Compared to the HCs, the DD-CKD patients had elevated small-worldness (σ) and normalized clustering coefficient (P<0.01) values, while no significant statistical differences were observed between NDD-CKD patients and the HCs. The clustering coefficient (P<0.05), and global and local efficiency (P<0.01) values were decreased, while the characteristic path length (P<0.01) was increased in the CKD patients, especially those who were DD. The CKD patients also had decreased DTI-ALPS index (P=0.001) and increased CPV (P<0.001) values. These indicators were correlated with verbal memory, anxiety, and depression levels (all P<0.05). The mediation analysis revealed that σ partially mediated the effect of the DTI-ALPS index on depression levels (mediation effect: -5.0404), σ fully mediated the effect of the CPV on depression levels (mediation effect: 0.0013), and σ fully mediated the effect of the DTI-ALPS index on anxiety levels (mediation effect: -5.9291). Conclusions: CKD patients exhibit impaired glymphatic system function and abnormal white-matter network topology, both of which are correlated with cognition, verbal memory, and emotional states. The structural integrity and organizational efficiency of white-matter networks may be a critical factor linking glymphatic dysfunction to emotional health in CKD patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.