ArticleTransboundary and emerging diseases2025
Emergence of a PRRSV Strain Recombined From Two Modified-Live Virus Vaccines and Its Elimination From a Breeding Herd.
Article in Transboundary and emerging diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Emergence of a Novel Porcine Reproductive and Respiratory Syndrome Virus 2 Strain Recombined from Two Modified Live Virus-like Strains and Its Pathogenicity for Piglets.Animals : an open access journal from MDPI · 2026Article
- Genetic Characterization of PRRSV Diversity and Detection of Other Pathogens in Live Virus Inoculation Material Used in Breeding Herd Stabilization Programs.Microorganisms · 2026Article
- Cross-Protection in PRRSV: Mechanisms, Limitations, and Implications for Vaccine Design.Pathogens (Basel, Switzerland) · 2026Review
- Comparative epidemiology and preparedness for African swine fever and porcine reproductive and respiratory syndrome in four major Asian swine industries.Frontiers in veterinary science · 2026Review
- Evaluating NGS-generated contig accuracy for detection and assignment of PRRSV against a reference genome in experimentally mixed PRRSV infection samples.Frontiers in veterinary science · 2026Article
- Genetic and Pathogenic Characteristics of an Emerging Lineage 7 PRRSV-2 (Prime Pac-Like) Strain in China.Transboundary and emerging diseases · 2025Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Porcine reproductive and respiratory syndrome (PRRS) is one of the most challenging diseases for swine production. The PRRS virus (PRRSV) is an RNA virus that replicates via an RNA-dependent RNA polymerase (RDRP) mechanism, which is prone to high mutation rates. Recombinations are characterized by the exchange of genetic material across two or more viruses. Modified live virus (MLV) vaccines produce an immune response to PRRSV after replicating in pigs, similar to natural exposure. Here, we report the emergence of an MLV-like recombinant strain, its associated production impact, and its disappearance trajectory from a breeding herd. The emergent virus was identified and successfully eliminated from a 9248-sow breed-to-wean herd. Accidental usage of two distinct MLVs in the herd led to the recombination and emergence of a new strain. The clinical presentation was mild compared to current wild-type strains, with the associated production loss amounting to 549 weaned piglets per 1000 sows. Production levels returned to normal within 7 weeks. Transitory, no significative production loss in the wean-to-market phase was identified. Immunization of the herd and tightening of biosecurity and biocontainment practices were able to eliminate the virus from the herd, without evidence of broad regional spread.
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Registered trials
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