ReviewMaterials today. Bio2025
Multidimensional advances in neural interface technology for peripheral nerve repair: From material innovation to clinical translation.
Review in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- From blueprint to build: Metal ions in peripheral nerve development and engineering regeneration.Bioactive materials · 2026Review
- Flexible Multimodal Neural Probe with Integrated Three-Electrode Aptameric Sensing for In Vivo Monitoring of Dopamine Dynamics and Neural Activity.ACS chemical neuroscience · 2026Article
- Engineering halogen-doped carbon dots for enhanced bioinspired synapses toward neuromorphic computing and neural interfaces.Materials today. Bio · 2026Article
- RIPK3 Inhibition Mitigates Denervated Muscle Atrophy via NOX4-Mediated Mitochondrial Restoration and Inflammation Suppression.Journal of cachexia, sarcopenia and muscle · 2026Article
- Localized Tacrolimus Delivery for Peripheral Nerve Regeneration: Molecular Mechanisms, Biomaterial Platforms, and Translational Strategies.International journal of molecular sciences · 2026Review
- Bio-Compatibility Analysis of Newly Developed Plug and Cuff Electrodes for Future Neuronal Interface Applications.Biomimetics (Basel, Switzerland) · 2026Article
- Regenerative medicine approaches for the treatment of peripheral nerve injuries: progress and challenges.Regenerative biomaterials · 2026Review
- A Bio-Inspired Artificial Nerve Simulator for Ex Vivo Validation of Implantable Neural Interfaces Equipped with Plug Electrodes.Bioengineering (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review evaluates the research progress and clinical application potential of neural interface technology for peripheral nerve injury (PNI). Due to the limited endogenous regenerative capacity of the peripheral nervous system after injury, the impaired function of the innervated area seriously affects the life quality of patients. Neural interfaces offer a transformative strategy for functional reconstruction by establishing bidirectional communication pathways between the nervous system and external devices. Through a critical analysis of high-impact literature, this article develops a comprehensive review framework encompassing four key dimensions: advancements in material science, technological innovation pathways, clinical translation validation, and existing challenges. Current evidence demonstrates that neural interface materials evolved from traditional rigid substrates to flexible conductive polymers, multifunctional nanocomposites, biodegradable bioactive scaffolds, and environmentally responsive smart materials. Technological breakthroughs include tissue-compliant flexible micro-nano fabrication, wireless self-powered systems, closed-loop neural feedback control, and multimodal precision modulation. Preclinical and clinical researches validated the therapeutic efficacy of neural interfaces in promoting axon regeneration, managing chronic pain, and restoring sensorimotor function. However, persistent challenges (such as limited long-term interfacial stability, post-implantation inflammatory responses, signal quality attenuation, and interindividual therapeutic heterogeneity) hinder widespread clinical adoption. Future research should prioritize interdisciplinary integration to develop: physiologically adaptive material interfaces, intelligent closed-loop modulation systems, personalized treatment strategies with predictive modeling, and mechanistic insights into neuro-electronic interface interactions. These advances will enable neural interface technologies to achieve biosafety, functional durability, and therapeutic precision for revolutionary treatment paradigms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.