Evidence map›Paper›PMID 40727297›Full record

ArticleRSC advances2025

Designing parylene coating for implantable brain-machine interfaces.

Saman Ebrahimibasabi, Maryam Golshahi, Naghmeh Shahraki, Delaram Tamjid Shabestari, Mostafa Sajjadi, Seyedamin Hashemi, Austin Borchert, Ian Baker, Layla Khalifehzadeh, Hamed Arami

Abstract read
In one paragraph

Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Parylenes in bioanalytical and cell culture applications.Analytical and bioanalytical chemistry · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Saman EbrahimibasabiMaterials Science and Engineering, School for Engineering of Matter, Transport and Energy, Arizona State University Tempe AZ 85287 USA hamed.arami@asu.edu.ORCID https://orcid.org/0009-0009-7007-0833
Maryam GolshahiBiological Design Program, School for Engineering of Matter, Transport and Energy, Arizona State University Tempe AZ 85287 USA.
Naghmeh ShahrakiBiological Design Program, School for Engineering of Matter, Transport and Energy, Arizona State University Tempe AZ 85287 USA.
Delaram Tamjid ShabestariBiological Design Program, School for Engineering of Matter, Transport and Energy, Arizona State University Tempe AZ 85287 USA.
Mostafa SajjadiBiological Design Program, School for Engineering of Matter, Transport and Energy, Arizona State University Tempe AZ 85287 USA.
Seyedamin HashemiSchool of Electrical, Computer and Energy Engineering, Arizona State University Tempe AZ 85287 USA.ORCID https://orcid.org/0000-0001-9891-5409
Austin BorchertMaterials Science and Engineering, School for Engineering of Matter, Transport and Energy, Arizona State University Tempe AZ 85287 USA hamed.arami@asu.edu.
Ian BakerMaterials Science and Engineering, School for Engineering of Matter, Transport and Energy, Arizona State University Tempe AZ 85287 USA hamed.arami@asu.edu.
Layla KhalifehzadehChemical Engineering, School for Engineering of Matter, Transport and Energy, Arizona State University Tempe AZ 85287 USA layla.zadeh@asu.edu.
Hamed AramiMaterials Science and Engineering, School for Engineering of Matter, Transport and Energy, Arizona State University Tempe AZ 85287 USA hamed.arami@asu.edu.ORCID https://orcid.org/0000-0002-6409-4435

Funding

Magnetic Particle Imaging (MPI) for Imaging and Magnetothermal Therapy of Brain TumorsR00CA234208 · NCI · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI ARAMI, HAMED · 2022 to 2024
$742k
Flexible and Wireless Bioelectronics for Continuous Monitoring of Intracranial PressureR00EB031178 · NIBIB · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI KHALIFEHZADEH, LAYLA · 2022 to 2024
$724k
Magnetic Particle Imaging (MPI) for Imaging and Magnetothermal Therapy of Brain TumorsK99CA234208 · NCI · STANFORD UNIVERSITY · PI ARAMI, HAMED · 2020 to 2022
$477k
Flexible and Wireless Bioelectronics for Continuous Monitoring of Intracranial PressureK99EB031178 · NIBIB · STANFORD UNIVERSITY · PI KHALIFEHZADEH, LAYLA · 2021 to 2022
$191k
NCI NIH HHS K99 CA234208NCI NIH HHS R00 CA234208NIBIB NIH HHS K99 EB031178NIBIB NIH HHS R00 EB031178
6 · The paper itself

Abstract

Parylene is widely recognized as an effective candidate for encapsulating implantable bioelectronics due to its outstanding chemical stability, conformity and biocompatibility. However, its weak adhesion to inorganic substrates remains a significant challenge. Here, we explored various pre- and post-deposition treatments to enhance adhesion and stability of parylene coating for implantable brain-machine interfaces (BMIs). We utilized 0%, 0.5%, 1%, and 1.5% (v/v) 3-(trimethoxysilyl)propyl-methacrylate as an adhesion promoter for substrate treatment prior to deposition. Deposited samples were subsequently subjected to post-heat treatments at various temperatures. Samples were exposed to an

Identifiers

PMID40727297
PMCPMC12301961

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.