ArticleRSC advances2025
Thiazole conjugated amino acid derivatives as potent cytotoxic agents.
Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
12 authors.
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Abstract
In the search for anticancer agents, molecular hybridization has gained increasing attention due to its unique advantages like enhanced pharmacological activity, reduced toxicity, and circumvention of drug resistances. In this study, by incorporating amino acids into the thiazole heterocycle scaffold, thirty thiazole-amino acid hybrid derivatives have been successfully synthesized and tested for cytotoxicity against the three human cancer cell lines including lung cancer (A549), cervical cancer (HeLa), and breast cancer (MCF-7) cell lines. The results showed that most of the synthesized hybrid thiazole-amino acids exhibited moderate to good cytotoxicity towards the tested cancer cell lines. Notably, five compounds displayed good cytotoxicity with low IC
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