Evidence map›Paper›PMID 40727258›Full record

ArticleJournal of Alzheimer's disease reports

The association of specific and cumulative exposure to infectious agents with cognitive impairment in older Hispanic adults.

Giselle A Rangel, Berta A Muñoz, Morgan Ramirez, Kristen Wroblewski, Alcibiades E Villarreal, Diana C Oviedo, Maria B Carreira, Rima McLeod, Gabrielle B Britton, Panama Aging Research Initiative – Health Disparities (PARI-HD) study

Abstract read
In one paragraph

Article in Journal of Alzheimer's disease reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Giselle A RangelDepartamento de Neurociencias, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT-AIP), Ciudad del Saber, Panama City, Panama.ORCID https://orcid.org/0000-0001-6825-3803
Berta A MuñozEscuela de Tecnología Médica, Facultad de Medicina, Universidad de Panamá (UP), Panama City, Panama.ORCID https://orcid.org/0009-0006-6271-5484
Morgan RamirezDepartments of Ophthalmology and Visual Sciences, Pediatrics (Infectious Diseases), The College Center of Global Health, University of Chicago, Chicago, IL, USA.ORCID https://orcid.org/0009-0001-2453-212X
Kristen WroblewskiDepartment of Public Health Sciences, University of Chicago, Chicago, IL, USA.ORCID https://orcid.org/0000-0001-9297-0394
Alcibiades E VillarrealDepartamento de Neurociencias, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT-AIP), Ciudad del Saber, Panama City, Panama.ORCID https://orcid.org/0000-0002-6684-0593
Diana C OviedoDepartamento de Neurociencias, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT-AIP), Ciudad del Saber, Panama City, Panama.ORCID https://orcid.org/0000-0003-1987-5205
Maria B CarreiraDepartamento de Neurociencias, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT-AIP), Ciudad del Saber, Panama City, Panama.ORCID https://orcid.org/0000-0001-5306-0021
Rima McLeodDepartments of Ophthalmology and Visual Sciences, Pediatrics (Infectious Diseases), The College Center of Global Health, University of Chicago, Chicago, IL, USA.ORCID https://orcid.org/0000-0002-1130-9631
Gabrielle B BrittonDepartamento de Neurociencias, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT-AIP), Ciudad del Saber, Panama City, Panama.ORCID https://orcid.org/0000-0002-1758-2495
Panama Aging Research Initiative – Health Disparities (PARI-HD) study

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Accumulating evidence implicates infectious pathogens as triggers of immune-inflammatory processes that contribute to neurodegeneration. Inflammation in both the brain and peripheral circulation is recognized as a critical factor in the development and progression of cognitive decline and neurodegenerative disorders, including Alzheimer's disease. Objective: This retrospective case-control study investigated the association between cognitive impairment and presence of serum antibodies to seven pathogens in older adults. Methods: One hundred sixty-five participants aged ≥ 65 years from the Panama Aging Research Initiative Health Disparities (PARI-HD) study were evaluated. Presence of IgG antibodies against Results: Only Conclusions: These results enhance our understanding of cognitive impairment in a Hispanic population and underscore the need for further studies on the role of

Indexed as

Alzheimer's diseaseantibodiesChlamydia pneumoniaecognitive impairmentinflammation

Identifiers

PMID40727258
PMCPMC12301615

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.