Evidence map›Paper›PMID 40727255›Full record

ArticlePhysics and imaging in radiation oncology2025

Comparison of interstitial high-dose-rate brachytherapy and stereotactic radiotherapy in breath-hold technique for inoperable primary and secondary liver tumors.

Philipp Geissler, Saskia Spautz, Kathrin Hering, Isabell Seiler, Frank Heinicke, Ilias Sachpazidis, Dimos Baltas, Sebastian Schäfer, Christos Moustakis, Nils H Nicolay and 1 more

Abstract read
In one paragraph

Article in Physics and imaging in radiation oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Philipp GeisslerDepartment of Radiotherapy, University Hospital Leipzig, Leipzig, Germany.
Saskia SpautzDepartment of Radiotherapy, University Hospital Leipzig, Leipzig, Germany.
Kathrin HeringDepartment of Radiotherapy, University Hospital Leipzig, Leipzig, Germany.
Isabell SeilerDepartment of Radiotherapy, University Hospital Leipzig, Leipzig, Germany.
Frank HeinickeDepartment of Radiotherapy, University Hospital Leipzig, Leipzig, Germany.
Ilias SachpazidisDivision of Medical Physics, Department of Radiation Oncology, Medical Centre - University of Freiburg, Medical Faculty - University of Freiburg, German Cancer Consortium (DKTK), Partner Site DKTK, Freiburg, Germany.
Dimos BaltasDivision of Medical Physics, Department of Radiation Oncology, Medical Centre - University of Freiburg, Medical Faculty - University of Freiburg, German Cancer Consortium (DKTK), Partner Site DKTK, Freiburg, Germany.
Sebastian SchäferDepartment of Radiotherapy, University Hospital Leipzig, Leipzig, Germany.
Christos MoustakisDepartment of Radiotherapy, University Hospital Leipzig, Leipzig, Germany.
Nils H NicolayDepartment of Radiotherapy, University Hospital Leipzig, Leipzig, Germany.
Franziska NäglerDepartment of Radiotherapy, University Hospital Leipzig, Leipzig, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and purpose: In recent years, ablative radiotherapy of primary and secondary liver tumors has become a highly regarded treatment option. We aimed to compare high-dose-rate interstitial brachytherapy (HDR-iBT) and stereotactic body radiotherapy (SBRT) in free breathing (FB) and deep inspiration breath hold (DIBH) in order to support future decisions on the appropriate radiation technique for liver tumors. Materials and methods: Forty-two patients with 1-4 liver malignancies undergoing HDR-iBT with 1x15-20 Gy were included. Eighty-eight SBRT plans in DIBH or FB with a prescription dose of 3x12.5 Gy to the surrounding 67 % isodose were generated using the HDR-iBT-computed tomography. Dose-volume parameters according to ICRU91 regarding organs-at-risk (OAR), target coverage, generalized equivalent uniform dose (gEUD Results: The mean target doses for HDR-iBT were at least twice as high as in SBRT, but target coverage was significantly more conformal for SBRT and the gEUD Conclusion: While SBRT

Indexed as

BrachytherapyHepatocellular carcinomaLiver metastasesPlan comparisonRadiotherapyStereotactic radiotherapy

Identifiers

PMID40727255
PMCPMC12301820

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.