ArticlePeerJ2025
The value of inflammatory indices in the diagnosis of acute appendicitis and prediction of complicated appendicitis: a retrospective study.
Article in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Diagnostic Accuracy of Inflammatory Biomarkers in Differentiating Acute Appendicitis From Other Acute Abdomen and Predicting Disease Severity: A Prospective Comparative Cross-Sectional Study.Health science reports · 2026Article
- Diagnostic value of CAR, HALP, and SII for predicting complicated appendicitis: a reassessment of inflammatory indices.BMC surgery · 2026Article
- A multicenter prospective cohort study developing and validating a SIRI-based machine learning model and simplified risk score for predicting postherpetic neuralgia.Frontiers in immunology · 2026Article
- Discriminative Utility of Peripheral Blood Immune-Inflammatory Indices for Chronic Osteomyelitis: A Single-Center Retrospective Case-Control Study.Infection and drug resistance · 2026Article
- Development and validation of a diagnostic nomogram based on peripheral blood composite inflammatory markers for complicated acute appendicitis: a retrospective study.Frontiers in surgery · 2026Article
- The Role of Emerging Immune-Inflammatory Indexes in the Preoperative Differentiation of Complicated and Uncomplicated Acute Appendicitis: A Single-Center Retrospective Analysis.Diagnostics (Basel, Switzerland) · 2025Article
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Authors and funding
7 authors.
Funding
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Abstract
Background: Acute appendicitis is a common cause of acute abdominal pain, typically treated surgically, although medical management is also an option. Laboratory investigations play a valuable role in diagnosis and predicting prognosis. We aimed to investigate and compare the effectiveness of indices such as the Systemic Immune-Inflammation Index (SII), Systemic Inflammatory Response Index (SIRI), and Pan-Immune-Inflammatory Value (PIV), all derived from complete blood count, in diagnosing acute appendicitis and distinguishing between complicated and uncomplicated cases. Methods: We retrospectively analyzed data from 334 patients diagnosed with acute appendicitis and 350 healthy individuals. The SII, SIRI, and PIV parameters were compared between the acute appendicitis group and the healthy group. The SII, SIRI, and PIV parameters were also compared between the complicated and uncomplicated groups. Results: All three parameters demonstrated good performance in predicting the diagnosis of appendicitis. An SII value above 1,008.43 ( Conclusions: All three indices showed good predictive performance for diagnosing appendicitis and acceptable performance for predicting complicated cases. Among the indices, SIRI was slightly superior to the other two in both scenarios.
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