ArticleIndian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India2025
The Relationship Between Tinnitus and Hematological Parameters: A Case-Control Study.
Article in Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Tinnitus, defined as the perception of sound without an external acoustic stimulus, has a multifactorial etiology, including metabolic, vascular, and neuro-otological factors. Microvascular dysfunction has been proposed as a possible mechanism in its pathogenesis. This study aimed to investigate whether changes in hematological parameters-specifically mean platelet volume (MPV), neutrophil/lymphocyte ratio (NLR), and platelet/lymphocyte ratio (PLR)-are associated with tinnitus. In this retrospective case-control study, 100 patients aged 18-59 with tinnitus and 100 age- and sex-matched healthy controls were included. Controls underwent hearing screening during the same period. Subjects with hearing loss, anatomical ear abnormalities, or systemic diseases were excluded. Hematological values including hemoglobin, neutrophil, lymphocyte, platelet counts, MPV, NLR, and PLR were recorded and compared between groups. Neutrophil and lymphocyte counts were significantly higher in the tinnitus group. However, both NLR and PLR values were significantly lower in these patients compared to controls ( Supplementary Information: The online version contains supplementary material available at 10.1007/s12070-025-05556-8.
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