ArticleIndian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India2025
Profiling Expression of BRAC2 Gene in Cases of Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders-A Retrospective Study.
Article in Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Oral potentially malignant disorders (OPMD) are heterogeneous mucosal lesions of the oral cavity that have a higher chance of developing into malignancy, such as oral squamous cell carcinoma (OSCC), in contrast to their normal and other diseased counterparts. Information on diagnosed cases of OSCC and OPMDs at different grading stages was stored in the department's archives. The diagnosis was assessed and confirmed by two oral pathologists. They were sent for immunohistochemical examination after receiving their individual formalin-fixed, paraffin-embedded (FFPE) samples from the Department's archives. Accordingly, this study discovered that the BRCA2 gene, also known as the tumour suppression gene (TSG), was expressed in cases of OSCC and OPMDs. The results showed that when grade or severity increased, neither group's expression of this gene changed. We therefore conclude that a large number of studies with sample sizes would be necessary to confirm the findings, as well as to employ new tissue samples to confirm the expression of the BRCA2 gene and to incorporate methods like qPCR and Western blot (WB).
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