Evidence map›Paper›PMID 40727115›Full record

ArticleJournal of medical cases2025

Influenza A H1N1 Triggering Complement-Mediated Hemolytic Uremic Syndrome.

Sathwik Madireddy, MacKenzie Adams, Boris Martinez Recinos

Abstract readCase Reports
In one paragraph

Article in Journal of medical cases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sathwik MadireddyDepartment of Medicine, Brown University, Providence, RI 02912, USA.
MacKenzie AdamsDepartment of Medicine, Brown University, Providence, RI 02912, USA.
Boris Martinez RecinosDepartment of Medicine, Brown University, Providence, RI 02912, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Complement-mediated hemolytic uremic syndrome (CM-HUS) is a condition characterized by hemolytic anemia, thrombocytopenia, and renal impairment, typically associated with a chronic dysregulation of the complement system. Few adult cases of CM-HUS triggered by influenza infection have been described. Here we present a case of a 56-year-old female with multiple myeloma receiving cancer treatment who presented with Influenza A H1N1-associated CM-HUS. She was treated with anti-complement therapy and at her 1-month follow-up had complete resolution of renal dysfunction and hemolytic anemia. This case highlights influenza infection as a trigger for CM-HUS in an immunocompromised adult and the role of anti-complement therapies.

Indexed as

Atypical HUSCM-HUSInfluenza

Identifiers

PMID40727115
PMCPMC12292013

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.