A Heart of Myeloid: Extramedullary Chronic Myelomonocytic Leukemia-2 Presenting as a Myeloid Sarcoma of the Pericardium Causing Recurrent Pericardial Effusions.

Austin Frisch, Rohan Boyapati, Ruja Parikh, Geetha Menezes, Niharika Tipirneni, Germame Ajebo, Danielle Shafer

Abstract readCase Reports

In one paragraph

Article in Journal of medical cases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

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5 · Who and what money

Authors and funding

7 authors.

Austin FrischDepartment of Internal Medicine, Inova Fairfax Medical Center, Falls Church, VA, USA.

Rohan BoyapatiUniversity of Virginia School of Medicine, Charlottesville, VA, USA.

Ruja ParikhUniversity of Virginia School of Medicine, Charlottesville, VA, USA.

Geetha MenezesDepartment of Pathology, Inova Fairfax Medical Center, Falls Church, VA, USA.

Niharika TipirneniDepartment of Medical Critical Care Services, Inova Fairfax Medical Center, Falls Church, VA, USA.

Germame AjeboInova Schar Cancer Center, Inova Fairfax Medical Center, Falls Church, VA, USA.

Danielle ShaferInova Schar Cancer Center, Inova Fairfax Medical Center, Falls Church, VA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic myelomonocytic leukemia (CMML) is a rare neoplasm that has a roughly 15-30% chance of transforming into acute myeloid leukemia (AML). Acute leukemias have been known to cause pleural or pericardial effusions but having CMML transform into AML while presenting as a cardiac myeloid sarcoma causing pericardial effusions makes this case unique. A 59-year-old patient presented to the emergency room with shortness of breath and was found to be in cardiac tamponade requiring urgent care. The thoracic surgery team performed a pericardiectomy and placed a window drain. Cardiac tissue biopsy proved cardiac myeloid sarcoma with immature blasts and myeloid cells. Initial bone marrow biopsy on admission showed hypercellularity with 19% blasts and abnormal monocytes with multilineage dysplasia on aspirate differential, with positive KRAS and TET2 mutations on next-generation sequencing analysis. There was no evidence of a BCR/ABL1 fusion on fluorescence

Indexed as

AMLCardiac myeloid sarcomaCMMLPericardial effusion

Identifiers

PMID40727113

DOI10.14740/jmc5144

PMCPMC12292012

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