ArticleFrontiers in pharmacology2025
Impact of complex interventions on antibacterial therapy and etiological diagnostics in community-acquired pneumonia: a 12-month pre- and post-intervention study.
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Standardized Prospective Intervention in Hospitalized Patients with Bacterial Pneumonia.Journal of clinical medicine · 2025Article
- Antimicrobial Resistance in the Era of Climate Change: Why We Should All Embrace and Integrate the One Health Approach in Clinical Practice?Antibiotics (Basel, Switzerland) · 2025Review
- Adherence to Antibacterial Therapy and Associated Factors in Lower Respiratory Infections in War-Affected Areas: A Randomized Controlled Trial.Antibiotics (Basel, Switzerland) · 2025Article
- Antimicrobial Resistance of Non-Fermenting Gram-Negative Bacilli in a Multidisciplinary Hospital in Romania.Biomedicines · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Antimicrobial resistance (AMR) is a growing global health concern, with community-acquired pneumonia (CAP) remaining a leading cause of hospitalization and empirical antibiotic use. However, adherence to clinical guidelines in CAP management is inconsistent, particularly in resource-limited settings. Objectives: This study aimed to evaluate the impact of a complex antimicrobial stewardship intervention on the quality of antibacterial therapy and diagnostic practices in hospitalized patients with CAP in Aktobe, Kazakhstan. Methods: A 12-month pre- and post-intervention study was conducted in two multidisciplinary hospitals. The intervention included educational sessions, implementation of protocol-based care, and improved access to diagnostic tools. Key indicators assessed included adherence to national antibiotic guidelines, use of severity scoring tools, timely antibiotic administration, microbiological diagnostics, and step-down therapy. Results: Significant improvements were observed in several indicators: guideline-adherent antibiotic prescribing increased from 75% to 93.5% (p < 0.001), step-down therapy from 2.7% to 8.2% (p = 0.021), and use of CURB-65/CRB-65 from 0% to 8.7% (p < 0.001). Use of urinary antigen tests increased from 0% to 12% (p < 0.001), while evaluation of antibiotic effectiveness at 48-72 h rose from 40.2% to 70.1% (p < 0.001). Multivariable logistic regression confirmed the independent impact of the intervention, adjusting for factors such as age, pneumonia severity, and shift type (day shift vs off-duty shift). Conclusion: A targeted, context-specific intervention significantly improved key quality indicators in CAP management. These findings support the effectiveness of multifaceted stewardship strategies in improving clinical practice and mitigating AMR.
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