ArticleMaterials today. Bio2025
Lactate-functionalized 3D-printed PCL/nHA scaffold drives BMSC osteogenesis via metabolic-epigenetic crosstalk.
Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- H3K18la in periodontal ligament fibroblasts regulates immune niches and alveolar bone remodeling under mechanical loads.International journal of oral science · 2026Article
- Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Biofunctional carboxymethyl chitosan hydrogels with nano-hydroxyapatite gradients accelerate bone defect healing.iScience · 2026Article
- Lactate-Mediated Lysine Lactylation in Renal Fibrosis: Current Progress and Challenges.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Review
- Three-dimensional printed PCL/nHA scaffolds promote soft tissue functional fibrosis to repair chest wall defect via Piezo1/CaBioactive materials · 2026Article
- The emerging role of lactate in skeletal homeostasis and disorders: Integrated mechanisms and translational opportunities.Journal of orthopaedic translation · 2026Review
- Materiobiology-guided regulation of mesenchymal stromal cell fate for aging-related diseases: From basic parameter design to clinical application.Bioactive materials · 2026Review
- Lactate and lactylation in osteoporosis: pathogenesis, regulation, and future perspectives.Journal of bone and mineral metabolism · 2026Review
- Tannic acid-assisted mechanical training transforms natural hydrogels into robust and bioactive membranes for guided bone regeneration.Materials today. Bio · 2026Article
- When metabolic enzymes meet lactylation: a bidirectional dialogue in health and disease.Frontiers in cell and developmental biology · 2026Review
- Functional impacts of lactylation in Hypoxia‒primed mesenchymal stromal cells.Frontiers in cell and developmental biology · 2025Review
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Authors and funding
6 authors.
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Abstract
Critical-sized bone defects pose significant clinical challenges due to the limited regenerative potential of human bone mesenchymal stem cells (BMSCs). To address this, we developed a 3D-printed polycaprolactone/nano-hydroxyapatite scaffold functionalized with sodium lactate (PCL/nHA/SL) to synergistically integrate structural support with metabolic-epigenetic modulation. The lactate-functionalized scaffold demonstrated excellent biocompatibility, facilitating BMSC adhesion, proliferation, and osteogenic differentiation. Compared to non-functionalized controls, the PCL/nHA/SL scaffold markedly enhanced osteogenesis, as evidenced by accelerated mineralization and upregulation of key osteogenic markers. Proteomic analysis revealed that lactate incorporation induced lysine lactylation modifications, with STAT1 identified as a central regulatory target. Mechanistic studies established that lactylation redirected STAT1 subcellular localization, thereby liberating RUNX2 to activate osteogenic transcriptional programs. Genetic validation underscored the critical role of STAT1 lactylation in orchestrating this metabolic-epigenetic crosstalk.
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