ArticlePsychology research and behavior management2025
Causal Relationship Between Depression, Sleep Disorders, and Constipation: A Mendelian Randomization and Mediation Analysis.
Article in Psychology research and behavior management, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Advances in understanding intestinal microbiota mechanisms and intervention strategies for anxiety, depression, sleep disorders, and constipation.Frontiers in microbiology · 2026Review
- Postoperative pain after laparoscopic percutaneous extraperitoneal closure for inguinal hernia in children: a single-center retrospective study.BMC pediatrics · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: The study aims to investigate the causal relationship between depression, sleep disorders, and constipation using multivariable Mendelian randomization (MR) and mediation MR analysis. Additionally, the potential mediating effects of sleep disorders in the association between depression and constipation were evaluated. Methods: Genome-wide association study (GWAS) data were utilized to identify genetic variants associated with depression, sleep disorders, and constipation as instrumental variables (IVs). The inverse-variance weighted (IVW) method was applied as the primary analytical approach. The mediating role of sleep disorders was assessed through multivariable MR and mediation MR analysis, and sensitivity analyses were conducted to assess the robustness of the findings. Results: Depression was associated with a significantly increased risk of constipation (OR 1.26, 95% CI 1.11-1.44, Conclusion: Findings from this study provide evidence of a causal relationship between depression and constipation, with sleep disorders serving as a partial mediator. These findings offer novel insights into the mechanisms of depression-related constipation, highlighting the potential role of sleep disturbances as a therapeutic target.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.