Evidence map›Paper›PMID 40727007›Full record

ReviewEClinicalMedicine2025

The expanding role of GLP-1 receptor agonists: a narrative review of current evidence and future directions.

Areesha Moiz, Kristian B Filion, Michael A Tsoukas, Oriana H Y Yu, Tricia M Peters, Mark J Eisenberg

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in EClinicalMedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
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  19. GLP-1RAs and cardiovascular risk in HS: concerns about follow-up time and effect estimates.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026
    Article
  20. Article

20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Areesha MoizCentre of Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, Montreal, Canada.
Kristian B FilionCentre of Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, Montreal, Canada.
Michael A TsoukasDepartment of Medicine, McGill University, Montreal, Canada.
Oriana H Y YuCentre of Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, Montreal, Canada.
Tricia M PetersCentre of Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, Montreal, Canada.
Mark J EisenbergCentre of Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, Montreal, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have transformed obesity management, offering substantial weight loss and metabolic benefits. This review examines their expanding role, evaluating efficacy compared to alternative treatments, emerging indications, ongoing challenges, and future directions. Beyond obesity and type 2 diabetes, the therapeutic potential of GLP-1 RAs extends to a range of conditions such as cardiovascular disease, liver disease, neurodegenerative disease, and substance abuse disorders. While early concerns regarding pancreatic and thyroid cancer have been largely attenuated by recent evidence, issues such as gallbladder and biliary disorders, psychiatric safety, and perioperative aspiration risk require ongoing investigation. Additionally, observations of weight regain after treatment discontinuation and reductions in lean mass highlight the need for long-term, individualized strategies to sustain clinical benefits. The high cost and limited access to these medications raise critical policy and equity challenges. Future research must address these gaps, focusing on long-term safety, optimizing combination approaches, and evaluating the broader clinical and economic implications of widespread GLP-1 RA use. Funding: K.B.F. is supported by a William Dawson Scholar award from McGill University. T.M.P. is a Fond de Recherche du Québec-Santé (FRQS) research scholar. M.J.E. holds a James McGill Professor award from McGill University. The funding sources had no involvement in the conduct of this study, interpretation of results, or the preparation of this manuscript for publication.

Indexed as

Cardiometabolic outcomesCombination therapyGlucagon-like peptide-1 receptor agonistHealth policySafety

Identifiers

PMID40727007
PMCPMC12303005

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.