ArticleJournal of multidisciplinary healthcare2025
Causal Effects of Gut Microbiome on Tinnitus: A Mendelian Randomization Study.
Article in Journal of multidisciplinary healthcare, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- The Gut-Ear Axis: From Dysbiosis to Auditory and Vestibular Disorders.International journal of molecular sciences · 2026Review
- Association Between Gut Microbiota and HIV Infection Risk: Insights from Mendelian Randomization and 16S rRNA Amplicon Sequencing.Microorganisms · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
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Abstract
Background: Previous studies have identified a clinical association between gut microbiota (GM) and tinnitus; however, the potential causal relationship remains unclear. Therefore, we conducted a Mendelian randomization(MR) study to evaluate the potential causal effects of 412 gut microbiome features on tinnitus risk. Methods: In the study, we used pooled data from a genome-wide association study(GWAS) of gut microbes from a Dutch population. Summary statistics of tinnitus were drawn from the FinnGen R10 database. Inverse variance weighted, weighted median and MR-Egger were used to evaluate the potential causal link between GM and tinnitus. Results: The MR analysis revealed a negative association between the abundance of Conclusion: Our findings suggest potential causal effects of specific gut microbial taxa and pathways on tinnitus, highlighting promising targets for prevention and treatment. However, further research is needed to validate these associations and clarify underlying mechanisms.
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