Evidence map›Paper›PMID 40726977›Full record

ArticleFrontiers in immunology2025

IDO1-AhR axis increases T regulatory cells in

Rafaella Oliveira Dos Santos, Nani Oliveira Carvalho, Thiago Barros do Nascimento de Morais, Wlademir Braga Salgado Sobrinho, Maria Geuziane Soares da Cruz, Elaine Speziali de Faria, Fernanda Fortes de Araújo, Vanessa Peruhype Magalhães, Stefanie Costa Pinto Lopes, Adriana Malheiros and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Rafaella Oliveira Dos SantosInstituto Leônidas e Maria Deane (ILMD), Fiocruz Amazônia, Manaus, Amazonas, Brazil.
Nani Oliveira CarvalhoInstituto Leônidas e Maria Deane (ILMD), Fiocruz Amazônia, Manaus, Amazonas, Brazil.
Thiago Barros do Nascimento de MoraisInstituto Leônidas e Maria Deane (ILMD), Fiocruz Amazônia, Manaus, Amazonas, Brazil.
Wlademir Braga Salgado SobrinhoInstituto Leônidas e Maria Deane (ILMD), Fiocruz Amazônia, Manaus, Amazonas, Brazil.
Maria Geuziane Soares da CruzInstituto Leônidas e Maria Deane (ILMD), Fiocruz Amazônia, Manaus, Amazonas, Brazil.
Elaine Speziali de FariaInstituto René Rachou (IRR), Fiocruz Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Fernanda Fortes de AraújoInstituto René Rachou (IRR), Fiocruz Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Vanessa Peruhype MagalhãesInstituto René Rachou (IRR), Fiocruz Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Stefanie Costa Pinto LopesInstituto Leônidas e Maria Deane (ILMD), Fiocruz Amazônia, Manaus, Amazonas, Brazil.
Adriana MalheirosInstituto de Ciências Biológicas, Universidade Federal do Amazonas (UFAM), Manaus, Amazonas, Brazil.
Adolfo José da MotaInstituto de Ciências Biológicas, Universidade Federal do Amazonas (UFAM), Manaus, Amazonas, Brazil.
Helton da Costa SantiagoInstituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
Paulo Afonso NogueiraInstituto Leônidas e Maria Deane (ILMD), Fiocruz Amazônia, Manaus, Amazonas, Brazil.
Andréa Teixeira de CarvalhoInstituto René Rachou (IRR), Fiocruz Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Marcus Vinícius Guimarães de LacerdaInstituto Leônidas e Maria Deane (ILMD), Fiocruz Amazônia, Manaus, Amazonas, Brazil.
Pritesh LalwaniInstituto Leônidas e Maria Deane (ILMD), Fiocruz Amazônia, Manaus, Amazonas, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Malaria remains a significant public health challenge in Brazil, where Methods: Peripheral blood mononuclear cells (PBMCs) were stimulated in vitro with Results: Stimulation with Pv-iE lysate increased IDO-1 expression in CD14 Discussion: These findings highlight the role of IDO-mediated TRP catabolism and innate immune signaling in promoting a tolerogenic phenotype during

Indexed as

Indoleamine-Pyrrole 2,3,-DioxygenaseMalaria, VivaxPlasmodium vivaxReceptors, Aryl HydrocarbonT-Lymphocytes, RegulatoryAdultCytokinesFemaleHumansKynurenineMaleMiddle AgedMyeloid Differentiation Factor 88Signal TransductionTryptophanYoung AdultCytokinesIDO1 protein, humanIndoleamine-Pyrrole 2,3,-DioxygenaseKynurenineMyeloid Differentiation Factor 88Receptors, Aryl HydrocarbonTryptophanaryl hydrocarbon receptorimmune toleranceindoleamine 2,3-dioxygenasekynureninemalariaPlasmodium vivaxregulatory T cellstryptophan catabolism

Identifiers

PMID40726977
PMCPMC12301311

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.