Evidence map›Paper›PMID 40726835›Full record

ArticleJournal of arrhythmia2025

High-frequency content within the QRS complex can predict ventricular tachyarrhythmias in hypertrophic cardiomyopathy.

Takeshi Tsutsumi, Jun Yokomachi, Takafumi Nakajima, Kentaro Minami, Nami Takano, Kuniaki Iwasawa, Gaku Oguri, Shigeru Toyoda, Toshiaki Nakajima

Abstract read
In one paragraph

Article in Journal of arrhythmia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Takeshi TsutsumiDivision of Cardiology Eda Memorial Hospital Yokohama Kanagawa Japan.ORCID https://orcid.org/0000-0002-3213-3663
Jun YokomachiDivision of Cardiology Yuai Memorial Hospital Furukawa Ibaragi Japan.
Takafumi NakajimaDepartment of Cardiovascular Medicine Dokkyo Medical University Mibu Tochigi Japan.
Kentaro MinamiDepartment of Cardiovascular Medicine Dokkyo Medical University Mibu Tochigi Japan.
Nami TakanoDepartment of the Internal Medicine Hospital of the Imperial Household Chiyoda-Ku Tokyo Japan.
Kuniaki IwasawaDivision of Health Service Promotion University of Tokyo Bunkyou-Ku Tokyo Japan.
Gaku OguriDepartment of Cardiovascular Medicine University of Tokyo Hospital Bunkyou-Ku Tokyo Japan.
Shigeru ToyodaDepartment of Cardiovascular Medicine Dokkyo Medical University Mibu Tochigi Japan.
Toshiaki NakajimaDepartment of Cardiovascular Medicine Dokkyo Medical University Mibu Tochigi Japan.ORCID https://orcid.org/0000-0001-9545-7529

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Frequency analysis of the electrocardiographic QRS complex (QRS) was performed to evaluate the abnormal ventricular excitation in hypertrophic cardiomyopathy (HCM), from which we validated a risk stratification for lethal ventricular arrhythmias (L-VAs). Methods: We selected 32 patients with HCM and 60 control subjects from a population of 520 consecutive patients with syncopal seizures in a university hospital. We measured bipolar X, Y, and Z leads and calculated the frequency power using continuous wavelet transform (CWT). We compared frequency powers, ranging from 15 to 250 Hz, between patients with HCM with and without L-VAs. ROC curve analysis was applied to evaluate the differences between groups. Results: The frequency powers of the QRS were increased in HCM in the wide frequency ranges, except for 49-62 Hz. The sum of the frequency power from 150 to 250 Hz was significantly higher in HCM with versus without L-VAs. The area under the ROC curve was 0.83. The occurrence of L-VAs could be predicted with a sensitivity of 0.92 and a specificity of 0.56. Conclusion: The high-frequency power hidden in the QRS may be a valuable predictor of L-VAs in patients with HCM.

Indexed as

electrocardiographic QRS complexhypertrophic cardiomyopathyventricular arrhythmiawavelet transform

Identifiers

PMID40726835
PMCPMC12301628

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.