ArticleTranslational animal science2025
Increasing dietary soybean trypsin inhibitor protein attenuates nursery pig performance.
Article in Translational animal science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Recent updates on amino acid requirements of pigs based on phenotypic improvements: invited review.Animal bioscience · 2026Article
- Dietary soybean-derived trypsin inhibitor protein reduces nursery pig performance and may exacerbate F18 enterotoxigenic Escherichia coli disease.Journal of animal science · 2026Article
- Effects of increasing trypsin inhibitor on nursery pig growth performance, fecal dry matter, and nutrient digestibility.Translational animal science · 2026Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Trypsin inhibitor proteins are antinutritional compounds innate to soybeans that reduce protein digestibility, amino acid bioavailability, and growth performance of pigs. The objective of this study was to evaluate the impact of increasing levels of dietary trypsin inhibitor unit activity (TIU/mg) on nursery pig growth performance and health. In a 41-d study, 1,140 newly weaned nursery pigs (5.9 ± 0.34 kg BW) were allotted into split sex pens, blocked by body weight, assigned randomly to one of five dietary treatments (n = 19 pens/treatment) varying in TIU/mg concentration, and fed over three dietary phases. Treatments targeted 0.41, 1.32, 2.20, 3.08, and 3.96 TIU/mg of complete feed averaged over the three phases and were achieved by using a corn-soybean meal basal diet with added soybean flour. Analyzed dietary treatments averaged 0.61, 1.22, 2.19, 3.41, and 3.51 TIU/mg. Pen BW and feed disappearance were recorded at the start and end of each phase to calculate ADG, ADFI, and G:F. Fecal consistency was scored and recorded daily. On d 21 of the study, 10 pigs per treatment were sacrificed for intestinal sample collection. Data were analyzed with pen as the experimental unit, the random effect of block, and the fixed effect of TIU, including polynomial contrasts for linear and quadratic effects of 0.61 to 3.51 TIU/mg treatments. No quadratic responses to dietary TIU/mg activity were reported in any parameters. Overall, as active dietary TIU/mg increased, ADG, ADFI, and G:F linearly decreased (
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