ArticleEFSA journal. European Food Safety Authority2025
Guidance on the use of read-across for chemical safety assessment in food and feed.
Article in EFSA journal. European Food Safety Authority, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
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- Safety assessment of the substance 1,3-benzenedicarboxamide, 5-[[[EFSA journal. European Food Safety Authority · 2026Article
- Psychology of Eating the Future: Consumer Acceptance, Digital Influence and Behavioral Drivers of Novel Foods.Foods (Basel, Switzerland) · 2026Review
- Physicochemical characterisation of iron oxides and hydroxides applied as food additive E 172.Food chemistry: X · 2026Article
- The Role of ES&T in Advancing Environmental Toxicology and Chemical Risk Assessment: Past, Present, and Future.Environmental science & technology · 2026Review
- Safety assessment of the substance l-aspartic acid,EFSA journal. European Food Safety Authority · 2026Article
- Synthetic Biology Approaches to Enzymology in Food and Agriculture Systems.Journal of agricultural and food chemistry · 2026Review
- Use and Safety of Tyrphostin AG17 as a Stabilizer in Foods and Dietary Supplements Based on Toxicological Studies and QSAR Analysis.Foods (Basel, Switzerland) · 2026Article
- Risks Associated with Dietary Exposure to Contaminants from Foods Obtained from Marine and Fresh Water, Including Aquaculture.International journal of environmental research and public health · 2026Review
- Article
- Guidance on the scientific data requirements for an application for authorisation of a food additive submitted under Regulation (EC) No 1331/2008.EFSA journal. European Food Safety Authority · 2026Article
- Scientific opinion on the amendment of the specifications for vegetable carbon (E 153) as a food additive.EFSA journal. European Food Safety Authority · 2026Article
- Advancing the One Health Framework in EU Plant Protection Product Regulation: Challenges and Opportunities.Journal of xenobiotics · 2025Article
- Article
- Endocrine-Disrupting Chemicals and Male Infertility: Mechanisms, Risks, and Regulatory Challenges.Journal of xenobiotics · 2025Review
- Guidance on the use of read-across for chemical safety assessment in food and feed.EFSA journal. European Food Safety Authority · 2025Article
- Mechanistic read-across comes of age: a comparative appraisal of EFSA 2025 guidance, ECHA's RAAF, and good read-across practice.Frontiers in toxicology · 2025Review
Corrections and comments
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Authors and funding
27 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Read-across is a method used in chemical risk assessment to predict the toxicological properties of a target substance by using data from structurally and mechanistically similar substances, known as source substances. EFSA's Scientific Committee has developed an approach for using read-across in food and feed risk assessment. This method provides a step-by-step guide to applying read-across as part of a weight-of-evidence evaluation for individual substances. It includes an explanation of the key aspects to consider at each step of the read-across workflow, i.e. problem formulation, target substance characterisation, source substance identification, source substance evaluation, data gap filling, uncertainty assessment, conclusion and reporting. It highlights the importance of clarity, impartiality and quality to derive transparent and reliable read-across conclusions. A particular emphasis is placed on the analysis of uncertainty and whether the overall uncertainty can be lowered to tolerable levels by using standardised approaches, and/or additional data from new approach methodologies (NAMs). The guidance outlines methods to integrate data from NAMs to support read-across in the relevant steps, improving the robustness of the assessment. The ultimate goal is to equip risk assessors and applicants with a comprehensive framework to carry out read-across assessments systematically and transparently, thereby supporting the safety evaluation of chemicals in the food and feed chain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.